耗材描述
Dermorphin
产品活性:Dermorphin 是在两栖类皮肤中发现的一种天然七肽 μ-阿片受体 (MOR) 激动剂。Dermorphin 可用于抑制神经痛。
产品来源: https://www.medchemexpress.cn/Dermorphin.html
研究领域:GPCR/G Protein | Neuronal Signaling
作用靶点:Opioid Receptor
结构分类:酚类 | 多酚类 | 其他类 | 结构分类
In Vitro: Dermorphin, a peptide isolated from the skin of Phyllomedusa frogs and the peptide receptor (NOP) component by the endogenous agonist nociceptin/orphanin FQ (N/OFQ). In displacement binding studies at CHOhMu, Dermorphin and DeNo displac the binding of [3H]-DPN in a concentration dependent and saturable manner. Dermorphin displays an affinity of 7.17, while N/OFQ fails to displace [3H]-DPN at the Delta receptor. Dermorphin and DeNo stimulate the binding of GTPγ[35S] in a concentration dependent and saturable manner at the Mu receptor.
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