Neurotensin 产品活性：Neurotensin 是一种肠十三肽，作为有效的细胞有丝分裂原，作用于各种结肠直肠癌和胰腺癌，对神经降压素受体 (neurotensin receptor，NTR) 具有高亲和力。 产品来源： https://www.medchemexpress.cn/Neurotensin.html 研究领域：GPCR/G Protein | Neuronal Signaling 作用靶点：Neurotensin Receptor In Vitro: Neurotensin induces the expression of MIP-2, MCP-1, IL-1β and TNFα in murine microglial cells and stimulates IL-8 secretion in a non-transformed colon epithelial cell line stably transfected with the NTR. The high-affinity NTR, a member of the G-protein coupled receptor (GPCR) family, is present in a majority of human pancreatic and colorectal cancers, suggesting that Neurotensin (NT) may act in an endocrine fashion to affect tumor growth. Acting through the NTR1, Neurotensin is known to stimulate various signal transduction pathways, including intracellular calcium ([Ca2+]i), the mitogen-activated protein kinases (MAPKs), ERK and JNK, and various PKC isoforms. Treatment of HCT116 cells with Neurotensin (100 nM) significantly increases HCT116 cell migration (~3-fold) compared with vehicle treatment; pretreatment with Curcumin (10 μM) blocksthe stimulatory effect of NT on HCT116 cell migration. ctivation of MEK/ERK by NT and downstream induction of AP-1 transcription factors contributes to the proliferative effects of Neurotensin. 相关产品：Bioactive Compound Library Plus | Peptide Library | Neurotransmitter Compound Library | AF38469 | SBI-553 | LM11A-31 dihydrochloride | Neurotensin(8-13) | THX-B | SORT-PGRN interaction inhibitor 1 | AF40431 | SR 142948 dihydrochloride | ML314 | Latozinemab | Kinetensin | [Lys8, Lys9]-Neurotensin (8-13) | Levocabastine hydrochloride | Sortilin antagonist 1 | JMV 449 acetate | NTRC-824 | (S)-Osanetant | Acetyl neurotensin (8-13) | BVFP | Contulakin G | hNTS1R agonist-1 | SORT-PGRN interaction inhibitor 3 | VGD071 | [D-Trp11]-Neurotensin 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。