耗材描述
PACAP (1-27), human, ovine, rat TFA
产品活性：PACAP (1-27), human, ovine, rat TFA (PACAP 1-27 TFA) 是 PACAP-38 的 N-末端片段，是一种有效的 PACAP 受体拮抗剂，对大鼠 PAC1，大鼠 VPAC1 和人 VPAC2 的 IC50 值分别为 3 nM，2 nM 和 5 nM。
产品来源： https://www.medchemexpress.cn/pacap-1-27-human-ovine-rat-tfa.html
研究领域：GPCR/G Protein
作用靶点：PACAP Receptor
In Vitro: Radioligand receptor binding assays with I-monoiodinated PACAP (1-27), human, ovine, rat confirms the presence of PAC -receptors on AR4-2J cells, since PACAP (1-27), human, ovine, rat and PACAP(1–38) equipotently displaces radioligand binding with a Kd of 1-2 nM, whereas vasoactive intestinal peptide (VIP) is 1000-fold less potent. PACAP (1-27), human, ovine, rat exhibits a distinct and much higher susceptibility to VIP-amino acid substitutions. PACAP (1-27), human, ovine, rat has potency and binding affinity to stimulate IP3 and cAMP formation in AR4-2J cells.
In Vivo: The inhibitory effect of pituitary adenylate cyclase activating polypeptide (PACAP (1-27), human, ovine, rat) on the increase in total pulmonary resistance (RL) causes either by allergen or histamine in anaesthetized, ventilated guinea-pigs is studied. PACAP (1-27), human, ovine, rat given via i.v. infusion (0.045-4.5 nmol/kg/min) dose-dependently reduces the increase in RL caused by inhaled ovalbumin and histamine. At the highest dose, PACAP (1-27), human, ovine, rat prevents the increase in RL caused by ovalbumin and histamine completely. Infusion of PACAP (1-27), human, ovine, rat and the β2-adrenoceptor agonist, salbutamol (0.045-4.5 nmol/kg/min) inhibit the increase in RL similarly, but salbutamol increases the heart rate more than PACAP (1-27), human, ovine, rat.
相关产品：Bioactive Compound Library Plus | Peptide Library | PACAP (1-38), human, ovine, rat | PA-8 | PACAP (6-38), human, ovine, rat TFA | PAC1R antagonist 1 | PA-9 | PACAP (1-38), amide, Biotin-labeled | PACAP (1-27), human, ovine, rat | PACAP-38 (16-38), human, mouse, rat | [Arg-15,20,21,Leu17]-PACAP-Gly-Lys-Arg-NH2 | PACAP-Related Peptide (PRP), human
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