Tat-NR2B9c 产品活性：Tat-NR2B9c (Tat-NR2Bct; NA-1) 是一种 PSD-95 的抑制剂，抑制 PSD-95d2 (PSD-95 PDZ domain 2) 和 PSD-95d1 的 EC50 分别为 6.7 nM 和 670 nM。Tat-NR2B9c 扰乱了 PSD-95/NMDAR 的相互作用，抑制 PSD-95 和 NR2A 和 NR2B 结合的 IC50 值分别为 0.5 μM 和 8 μM。Tat-NR2B9c 还能抑制神经元一氧化氮合酶 (nNOS)/PSD-95 相互作用，具有神经保护作用。 产品来源： https://www.medchemexpress.cn/Tat-NR2B9c.html 研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling | Immunology/Inflammation 作用靶点：iGluR | NO Synthase In Vitro: Tat-NR2B9c is a PSD-95 inhibitor, with an EC50 of 6.7 nM for PSD-95d2, representing a >100-fold higher affinity for this domain than for PSD-95d1 (EC50, 0.67 μM). Tat-NR2B9c inhibits NMDAR2A, NMDAR2B, and NMDAR2C binding to PSD-95, with IC50s of 0.5 μM, ∼8 μM, and 0.75 μM, respectively.Tat-NR2B9c also blocks the interaction between PSD-95 and nNOS with an IC50 of ∼0.2 μM. Tat-NR2B9c reduces association of PSD-95 with GluN2B by ∼50% in the YAC128 striatum, decreases NMDA-induced p38 activation in YAC128 striatal tissue, but shows no effect on the NMDA-induced JNK activation. In Vivo: Tat-NR2B9c (10 nmol/g, i.v.) reduces infarction volume of male C57BL/6 mice, but has no effect at 3 nM/g. 相关产品：Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Peptide Library | Corticosterone | L-NAME hydrochloride | Mifepristone | Dizocilpine maleate | D-AP5 | NMDA | Midostaurin | L-Glutamic acid | L-Arginine | Evans Blue | CNQX | Kynurenic acid | Glycine | DMPO | L-Phenylalanine | NBQX | S-Nitroso-N-acetyl-DL-penicillamine | 1400W Dihydrochloride | Quinolinic acid | DETA NONOate | Cycloleucine | Human serum albumin | Isoquercetin | Ethacrynic acid | Methylene Blue | Fucoxanthin | L-NMMA acetate | Chondroitin sulfate | Tetrahydrobiopterin | Ifenprodil tartrate 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。