Nonapeptide-1 产品活性：Nonapeptide-1 (Melanostatine-5)，一种多肽类激素，是 MC1R 选择性拮抗剂 (Ki: 40 nM)。 Nonapeptide-1 是一种竞争性的 α-MSH 拮抗剂，可有效抑制黑素细胞中 α-MSH 诱导的细胞内 cAMP 和黑素体扩散 (IC50 分别为 2.5 nM 和 11 nM)。 Nonapeptide-1 抑制黑色素合成，可用于研究皮肤色素沉着和肾上腺类固醇生成的调节、皮肤癌。 产品来源： https://www.medchemexpress.cn/nonapeptide-1.html 研究领域：GPCR/G Protein | Neuronal Signaling 作用靶点：Melanocortin Receptor In Vitro: Nonapeptide-1 (153N-6) inhibits α-melanocyte hormone (α-MSH)-induced melanosome dispersion, with an IC50 value of 11 nM. Nonapeptide-1 (0.1 nM-1 μΜ, 30 min) inhibits α-MSH-induced intracellular cAMP levels in melanocytes, with an IC50 of 2.5 nM. Nonapeptide-1 (153N-6) shows highest affinity for MC1R (Ki: 40 nM) in COS-1 cells expressing human receptors, and is selective for MC1R over MC3R, MC4R, and MC5R (Ki: 0.47, 1.34, and 2.4 μΜ, respectively). Nonapeptide-1 (N-1A, 20 μΜ, 3 days) inhibits the basal melanin synthesis and reverses UVA-induced melanin increase in Human epidermal melanocytes (HEM cells) and HaCaT cells. Nonapeptide-1 (20 μΜ, 3 days) competes with α-MSH and downregulates the expression of MC1R, tyrosinase, TRP1, TRP2, and MITF via binding to MC1R in HaCaT cells and HEM cells. 相关产品：α-MSH | Melanotan I | SHU 9119 | BMS-470539 dihydrochloride | Bremelanotide Acetate | Nonapeptide-1 acetate salt | JNJ-10229570 | THIQ | Adrenocorticotropic Hormone (ACTH) (1-39), rat TFA | HS024 TFA | β-Melanocyte Stimulating Hormone (MSH), human TFA | Dersimelagon | MK-0493 | PF-00446687 | SNT-207707 | ACTH (1-17) (TFA) | Adrenocorticotropic Hormone (ACTH) (1-39), human(TFA) | MSG606 | SNT-207858 free base | [D-Trp8]-γ-MSH | Adrenocorticotropic Hormone (ACTH) (4-10), human | Agouti-related Protein (AGRP) (83-132) Amide (human) (TFA) | Fenoprofen | PF-07258669 | ACTH (11-24) | HS014 TFA | ML-00253764 hydrochloride | PG-931 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。