耗材描述
Glucagon (1-29), bovine, human hydrochloride
产品活性:Glucagon (1-29), bovine, human, porcine hydrochloride 是由胰腺 α 细胞产生的一种多肽激素。Glucagon (1-29), bovine, human, porcine hydrochloride 促进糖异生。Glucagon (1-29), bovine, human, porcine hydrochloride 可激活 HNF4α 并促进 HNF4α 磷酸化。
产品来源: https://www.medchemexpress.cn/glucagon-hydrochloride.html
研究领域:GPCR/G Protein
作用靶点:GCGR
In Vitro: Upon binding to its receptor Gcgr, Glucagon activates cAMP-PKA signaling to stimulate hepatic glucose production (HGP) and cause hyperglycemia.
Glucagon stimulates both hepatic kisspeptin1 production and gluconeogenesis.
Glucagon (100 nM) represses CYP7A1 mRNA expression in human primary hepatocytes.
Glucagon (100 nM) increases phosphorylayion of HNF4α.
In Vivo: Low-dose (20 μg/kg) Glucagon increases glycemia and does not stimulate insulin secretion in ambient-fed mice. High-dose (1 mg/kg) Glucagon lowers glycemia compared with PBS control and stimulates insulin secretion in ambient-fed mice.
相关产品:Semaglutide | Exendin-4 | Liraglutide | Glucagon (1-29), bovine, human | Exendin(9-39) amide | Retatrutide | Orforglipron | GLP-1(7-37) | GLP-1(7-36), amide acetate | MK 0893 | Adomeglivant | BETP | Cotadutide acetate | GLP-1R Antagonist 1 | Danuglipron | GLP-1(9-36)amide | GLP-2(1-33)(human) | Oxyntomodulin (bovine, porcine) | Lixisenatide | Beinaglutide | Lotiglipron | Survodutide | NNC-0640 | Mazdutide | GLP-1R agonist 2 | LGD-6972
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