D-JNKI-1 产品活性：D-JNKI-1 (AM-111) 是高效可渗透细胞的 JNK 抑制剂。序列: Asp-Gln-Ser-Arg-Pro-Val-Gln-Pro-Phe-Leu-Asn-Leu-Thr-Thr-Pro-Arg-Lys-Pro-Arg-Pro-Pro-Arg-Arg-Arg-Gln-Arg-Arg-Lys-Lys-Arg-Gly-NH2。 产品来源： https://www.medchemexpress.cn/D-JNKI-1.html 研究领域：MAPK/ERK Pathway 作用靶点：JNK In Vitro: D-JNKI-1 (AM-111; 1 μM-1 mM) treatment prevents apoptosis and loss of neomycin-exposed hair cells. In Vivo: D-JNKI-1 (AM-111; 10 μM) prevents nearly all hair cell death and permanent hearing loss induced by neomycin ototoxicity in the scala tympani of the guinea pig cochlea. Local delivery of D-JNKI-1 also prevents acoustic trauma-induced permanent hearing loss in a dose-dependent manner. D-JNKI-1 (0.3 mg/kg, i.p.) reverses these pathological events in the brain mitochondria of the rat and almost completely abolishes cytochrome c release and PARP cleavage. D-JNKI-1 (1 μg/kg, s.c.) results in a significant decrease in the disease activity index, and reduces the expression of CD4+ and CD8+ cells in mice. 相关产品：Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Peptide Library | SP600125 | Anisomycin | JNK-IN-8 | Chloramphenicol | Astragaloside IV | Guggulsterone | Benzbromarone | p-Cresyl sulfate potassium | Tomatidine | JNK Inhibitor VIII | Tanzisertib | Berberine sulfate | Polyphyllin I | Ginsenoside Re | CC-90001 | Urolithin B | Bentamapimod | Isovitexin | JNK-IN-7 | AS601245 | DB07268 | Lixisenatide | Halicin | SR-3306 | Sesamolin | BI-78D3 | CC-401 hydrochloride | Seratrodast | SY-LB-35 | Peramivir 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。