NIM811 产品活性：NIM811 ((Melle-4)cyclosporin; SDZ NIM811) 是一种具有口服活性的线粒体渗透转换 (mitochondrial permeability transition) 和亲环蛋白 (cyclophilin) 双抑制剂，对丙型肝炎病毒 (HCV) 具有很强的体外活性。 产品来源： https://www.medchemexpress.cn/NIM811.html 研究领域：Metabolic Enzyme/Protease | Anti-infection 作用靶点：Mitochondrial Metabolism | HCV In Vitro: NIM811 induces a concentration-dependent reduction of HCV RNA in the replicon cells with an IC50 of 0.66 μM at 48 h. In addition, the combination of NIM811 with a-IFN significantly enhances anti-HCV activities without causing any increase of cytotoxicity. NIM811 blocks the mitochondrial permeability transition induced by calcium and inorganic phosphate. In Vivo: NIM811 prevents mitochondrial depolarization thereby attenuates liver injury, stimulates regeneration and improves liver function and survival. 相关产品：Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Macrocyclic Compound Library | Peptide Library | MitoSOX Red | Rotenone | CCCP | Resiquimod | FCCP | Mito-TEMPO | UK-5099 | MPP+ iodide | Devimistat | Honokiol | IACS-010759 | Ribavirin | Deferiprone | Fumarate hydratase-IN-1 | U18666A | Ciprofloxacin | Artemisinin | CTPI-2 | Asunaprevir | AG-1478 | Glibenclamide | IMT1 | Myriocin | Grazoprevir | Tempo | EIDD-1931 | MFI8 | Lonidamine | Sofosbuvir | Perhexiline maleate 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。