Zeaxanthin dipalmitate 产品活性：Zeaxanthin dipalmitate (Physalien) 是一种枸杞衍生的类胡萝卜素，具有抗炎和抗氧化应激作用。Zeaxanthin dipalmitate 与 p2X7 受体 (Kd=81.2 nM) 和脂联素受体 1 (AdipoR1; Kd=533 nM) 以正剂量依赖性方式直接相互作用。Zeaxanthin dipalmitate 恢复乙醇中毒抑制的线粒体自噬 (autophagy) 功能。Zeaxanthin dipalmitate 可用于酒精性脂肪肝 (AFLD)、色素性视网膜炎 (RP) 的研究。 产品来源： https://www.medchemexpress.cn/zeaxanthin-dipalmitate.html 研究领域：Metabolic Enzyme/Protease | Membrane Transporter/Ion Channel | Autophagy 作用靶点：Adiponectin Receptor | P2X Receptor | Autophagy 来源：植物 | 茄科 | 枸杞 结构分类：萜类 | 二萜 In Vitro: Zeaxanthin dipalmitate (1 µM; 2 h) totally or partially reverses the down-regulation of Atg5, beclin-1, and LC3A/B by ethanol (250 mM), and the up-regulation of p62 by ethanol in BRL-3A cells. Zeaxanthin dipalmitate (1 µM; 2 h) partially recovers the ethanol-suppressed LC3B in BRL-3A cells. Zeaxanthin dipalmitate (1 µM; 2 h) partially recovers the ethanol-suppressed cell viability and ethanol-induced aspase-3/7 activity of BRL-3A cells. Zeaxanthin dipalmitate (1 µM; 2 h) recovers the ethanol-induced inhibition of mitophagy in BRL-3A cells. In Vivo: Zeaxanthin dipalmitate (10 mg/kg; p.o.; daily for 2 weeks) reduces the serum ALT and AST levels increased by long-term ethanol challenge in at AFLD Model. Zeaxanthin dipalmitate (10 mg/kg; p.o.; daily for 2 weeks) effectively attenuates the histological injury. Zeaxanthin dipalmitate (10 mg/kg; p.o.; daily for 2 weeks) attenuates the AFLD-induced hepatic apoptosis (reveal by caspase-3/7 activity) and inflammation (TNF-α) in rat. Zeaxanthin dipalmitate (approximately 4 μM; intravitreal injection for once) improves the visual behavior of rd10 mice and delays the degeneration of retinal photoreceptors. Zeaxanthin dipalmitate (approximately 4 μM; intravitreal injection for once) improves the light responses of photoreceptors, bipolar cells and retinal ganglion cells. Zeaxanthin dipalmitate (approximately 4 μM; intravitreal injection for once) reduces the expression of genes that are involved in inflammation, apoptosis and oxidative stress in rd10 mice. 相关产品：AdipoRon | BzATP triethylammonium salt | A-740003 | Sodium metatungstate | KN-62 | A 438079 hydrochloride | NF449 octasodium | Gefapixant | Aurintricarboxylic acid | JNJ-47965567 | Gramine | α,β-Methylene-ATP trisodium | PPADS tetrasodium | 5-BDBD | AZD9056 hydrochloride | BAY-1797 | JNJ-55308942 | AZ10606120 dihydrochloride | A-317491 | Camlipixant | PSB-12062 | AF-353 | A-804598 | GSK-1482160 | P2X3 antagonist 34 | BX430 | JNJ-54175446 | NF023 hexasodium | A 839977 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。