3',4'-Dimethoxyflavone 产品活性：3',4'-Dimethoxyflavone 是一种亲脂性黄酮，可分离自黄花九轮草 (Primula veris) 的叶子。3',4'-Dimethoxyflavone 可减少 PARP 的合成和积累，保护皮质神经元免受Parthanatos 通路诱导的细胞死亡。3',4'-Dimethoxyflavone 在人乳腺癌细胞中也是一种芳香烃受体 (aryl hydrocarbon receptor) 拮抗剂。3',4'-Dimethoxyflavone 能促进人体造血干细胞增殖。具有多种生物活性，包括抗氧化、抗癌、抗炎、抗动脉粥样硬化、降血脂和神经保护或神经营养作用。 产品来源： https://www.medchemexpress.cn/3-4-dimethoxyflavone.html 研究领域：Cell Cycle/DNA Damage | Epigenetics | Immunology/Inflammation | NF-κB | Metabolic Enzyme/Protease 作用靶点：PARP | Reactive Oxygen Species | Aryl Hydrocarbon Receptor 来源：植物 | 凤尾蕨科 | 凤了蕨 | 植物 | 其他科 结构分类：黄酮类 | 黄酮 In Vitro: 3',4'-Dimethoxyflavone (10 and 20 μM) has protection against the reduction in SH-SY5Y viability induced by Methylnitronitrosoguanidine (MNNG) (HY-128612). 3',4'-Dimethoxyflavone (6.25-25 μM) decreases the levels of PAR induced by MNNG in HeLa cells. 3',4'-Dimethoxyflavone (12.5, 25, 50 and 100 μM; 15-20 h) reduces cortical neuronal death induced by exposure to NMDA (HY-17551). 3',4'-Dimethoxyflavone (0.1-10 μM; 24 h) exhibits significant inhibition of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced EROD activity in MCF-7 and T47D cells. 3',4'-Dimethoxyflavone inhibits AhR-dependent CYP1A1 induction and AhR-mediated inhibition of estrogen-induced gene expression in T47D and MCF-7 breast cancer cells. 3′,4′-Dimethoxyflavone (2.5 μM; 7 days) promotes the proliferation of human hematopoietic stem cells. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Epigenetics Compound Library | Immunology/Inflammation Compound Library | Metabolism/Protease Compound Library | NF-κB Signaling Compound Library | Stem Cell Signaling Compound Library | Natural Product Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Antioxidant Compound Library | Reprogramming Compound Library | Oxygen Sensing Compound Library | Anti-Cardiovascular Disease Compound Library | Ferroptosis Compound Library | Pyroptosis Compound Library | Traditional Chinese Medicine Active Compound Library | Flavonoids Library | Neuroprotective Compound Library | Anti-Breast Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Parkinson's Disease Compound Library | Neurodegenerative Disease-related Compound Library | Mitochondria-Targeted Compound Library | Transcription Factor-Targeted Library | Anti-Cancer Natural Product Library | Anti-inflammatory Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | Human Metabolite Library | Mitochondrial Protection Compound Library | Metabolic Enzyme Compound Library | Anti-Ovarian Cancer Compound Library | Multi-Target Compound Library | Radioprotector Library | Mitophagy Compound Library | Bioactive Compound Library Max | Olaparib | Acetylcysteine | H2DCFDA | Deferoxamine mesylate | MitoSOX Red | Elesclomol | Quercetin | PD98059 | L-Ascorbic acid | XAV-939 | Mito-TEMPO | Talazoparib | Niraparib | Mitoquinone mesylate | Sulforaphane | CH-223191 | L-Glutathione reduced | Trolox | Saruparib | Dimethyl fumarate | Zinc Protoporphyrin | Pifithrin-α hydrobromide | FX-11 | Rucaparib | L-Kynurenine | FICZ | Diphenyleneiodonium chloride | Urolithin A | Sodium dichloroacetate | Berberine chloride 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。