Malabaricone B 产品活性：Malabaricone B 是一种天然存在的植物酚类物质，是一种具有口服活性的 α-葡萄糖苷酶 (α-glucosidase) 抑制剂，IC50 为 63.7 µM。Malabaricone B 具有抗癌、抗菌、抗氧化和抗糖尿病活性。 产品来源： https://www.medchemexpress.cn/malabaricone-b.html 研究领域：Metabolic Enzyme/Protease | Apoptosis 作用靶点：Glucosidase | Apoptosis 来源：植物 | 肉豆蔻科 | 肉豆蔻 结构分类：酚类 | 多酚类 | 酮、醛、酸 In Vitro: Malabaricone B shows selective toxicity to human lung cancer (A549), malignant melanoma (A375) and T cell leukemia (Jurkat) cell lines, without showing toxicity to human normal intestinal (INT407), human kidney (HEK293) and lung fibroblast (WI-38) cells. Among the chosen cancer cell lines, Malabaricone B shows maximum cytotoxicity to the A549 cells (IC50 = 8.1 μM), which is significantly better than that of curcumin (IC50 = 26.7 μM). The Malabaricone B-induced apoptosis is mediated by an increase in the intracellular reactive oxygen species (ROS). Malabaricone B (2.5, 5, 10 and 20 µM) increases the BAX level while simultaneously decreasing the BCL-2 and BCL-XL levels in the A549 cells, triggering the mitochondrial apoptotic pathway as revealed from the release of cytochrome c, and the activation of caspase-9 and caspase-3. Malabaricone B exhibits a good level of antimicrobial activity when tested against avariety of microorganisms, including Staphylococcus aureus and Candida albicans. In Vivo: Malabaricone B (100 mg/kg; p.o; alternate day, 23 days) inhibits lung tumor (xenograft) growth in SCID mice. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Anti-Infection Compound Library | Apoptosis Compound Library | Metabolism/Protease Compound Library | Natural Product Library | Anti-Cancer Compound Library | Anti-diabetic Compound Library | Medicine Food Homology Compound Library | Phenols Library | Orally Active Compound Library | Traditional Chinese Medicine Active Compound Library | Anti-Lung Cancer Compound Library | Anti-Blood Cancer Compound Library | Anti-Obesity Compound Library | Glucose Metabolism Compound Library | Anti-Cancer Natural Product Library | Plant-Sourced Natural Product Library | Human Metabolite Library | Metabolic Enzyme Compound Library | Cell Death Library | Anti-Hematopathy Compound Library | Bioactive Compound Library Max | MG-132 | Doxorubicin hydrochloride | Bafilomycin A1 | Tamoxifen | Y-27632 | LY294002 | Paclitaxel | Z-VAD-FMK | Acetylcysteine | Angiotensin II human | 2-Deoxy-D-glucose | Staurosporine | Actinomycin D | SB-431542 | 5-Fluorouracil | Bortezomib | Deferoxamine mesylate | Oxaliplatin | Trametinib | Sorafenib | Temozolomide | Gemcitabine | Decitabine | Mdivi-1 | Rotenone | Etoposide | Elesclomol | Ruxolitinib | Monomethyl auristatin E | DAPT 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。