耗材描述
Ailanthoidol
产品活性:Ailanthoidol 是一种天然的新木质素,具有抗炎、抗肿瘤的活性。Neolignan 在肿瘤进展找中起化学预防作用 。
产品来源: https://www.medchemexpress.cn/ailanthoidol.html
研究领域:Others
作用靶点:Others
来源:植物 | 芸香科 | 节木花椒
结构分类:苯丙素类 | 木脂素 | 酚类 | 单酚类 | 结构分类
In Vitro: Ailanthoidol (20 μM; 24-72 hours) showed no cytotoxicity toward RAW264.7 macrophages.
Ailanthoidol (1.25-20 μM; 24 hours) suppresses the generation of nitric oxide (NO) and prostaglandin E2 , aswell as theexpression of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 induced by lipopolysaccharide (LPS) in RAW264.7 cells.
Ailanthoidol (1.25-20 μM; 24 hours) inhibits the production of inflammatory cytokines induced by LPS in RAW264.7 cells, including interleukin (IL)-1b and IL-6.
Ailanthoidol suppresses NF-kB activation by blocking Ik-Ba degradation.
In Vivo: Ailanthoidol (0.1-10 mg/kg; i.g.; 24 hours and 1 hours before LPS was injected, for 5 days) protects BALB/c mice from LPS (25mg/kg)-induced endotoxin shock, possibly through inhibition of the production of inflammatory cytokines and NO.
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