Cyclocurcumin 产品活性：Cyclocurcumin 是一种有效的 p38α 抑制剂。Cyclocurcumin 具有抗风湿、抗血管收缩和抗氧化活性。 产品来源： https://www.medchemexpress.cn/cyclocurcumin.html 研究领域：MAPK/ERK Pathway 作用靶点：p38 MAPK 来源：植物 | 姜科 | 姜黄 结构分类：酚类 | 多酚类 | 结构分类 In Vitro: Cyclocurcumin (10-40 μM; 18 h) leads to significant inhibition in the release of TNF-α in a dose-dependent manner in LPS-stimulated human macrophages. Cyclocurcumin (5-25 μM) inhibits phenylephrine (HY-B0769)-induced vasocontraction in a concentration-dependent manner (IC50=14.9±1.0 μM) in freshly isolated rat aortic rings. Cyclocurcumin (5-25 μM; 30 min) inhibits influx of intracellular calcium in a dose-dependent manner. Cyclocurcumin inhibits L-type calcium channel-mediated vasoconstriction in a concentration-dependent manner. The anticontractile effect of Cyclocurcumin is reversible. Cyclocurcumin has strong activity as a scavenger of ˙OH and ˙OOH free radicals preferentially by its 4′-OH phenolic radical via a hydrogen-atom transfer mechanism in water and a physiological environment. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Kinase Inhibitor Library | MAPK Compound Library | Natural Product Library | Antioxidant Compound Library | Reprogramming Compound Library | Oxygen Sensing Compound Library | Anti-Cardiovascular Disease Compound Library | Phenols Library | Pyroptosis Compound Library | Traditional Chinese Medicine Active Compound Library | Anti-Lung Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Neurodegenerative Disease-related Compound Library | Anti-Obesity Compound Library | Angiogenesis-Related Compound Library | Food-Sourced Compound Library | Anti-Cancer Natural Product Library | Antidepressant Compound Library | Anti-inflammatory Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | Human Metabolite Library | Anti-Prostate Cancer Compound Library | Anti-Pulmonary Fibrosis Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Serine/Threonine Kinase Inhibitor Library | Anti-Ovarian Cancer Compound Library | Radioprotector Library | Bioactive Compound Library Max | Anti-Gastric Cancer Compound Library | Adezmapimod | SB 202190 | Afatinib | Doramapimod | Aspirin | Oxidopamine hydrobromide | BI-3406 | Butyzamide | Muramyl dipeptide | C16-PAF | Ergothioneine | Hesperetin | PD 169316 | Diprovocim | Ralimetinib dimesylate | Dehydrocorydaline | Naporafenib | Neflamapimod | Losmapimod | Fumaric acid | p-Cresyl sulfate potassium | Exarafenib | VX-702 | PF-3644022 | Lysophosphatidylcholines | Skatole | Talmapimod 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。