耗材描述
Gypenoside L
产品活性:Gypenoside L 是一种皂苷,存在于 Gynostemma pentaphyllum 中。Gypenoside L 增加 SA-β-半乳糖苷酶活性,促进衰老相关分泌细胞因子的产生。Gypenoside L 还可以激活 p38 和 ERK MAPK 通路和 NF-κB 通路以诱导衰老。Gypenoside L 具有抗肿瘤和抗炎活性。
产品来源: https://www.medchemexpress.cn/gypenoside-l.html
研究领域:MAPK/ERK Pathway | Stem Cell/Wnt | NF-κB
作用靶点:p38 MAPK | ERK | NF-κB
来源:植物 | 葫芦科 | 绞股蓝
结构分类:萜类 | 三萜
In Vitro: Gypenoside L (20-80 μg/mL; 24 h) increases the mRNA expression levels of SASP, such as IL-1α, IL-6, TIMP-1, CXCL-1 and CXCL-2 in HepG2 and ECA-109 cells.
Gypenoside L (20-80 μg/mL; 24 h) causes cell cycle arrest at S phase.
GPL (3.125-100 μg/mL) significantly inhibits LPS-induced NO accumulation in RAW264.7 cells.
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