耗材描述
Gypenoside LI
产品活性:Gypenoside LI 是一种绞股蓝赶单体,具有抗肿瘤活性。Gypenoside LI 诱导癌细胞凋亡、细胞周期阻滞和迁移。
产品来源: https://www.medchemexpress.cn/gypenoside-li.html
研究领域:Apoptosis | Epigenetics
作用靶点:Apoptosis | MicroRNA
来源:植物 | 葫芦科 | 绞股蓝
结构分类:萜类 | 三萜
In Vitro: Gypenoside LI (0-80 μM) inhibits A549 cells in a dose-dependent manner. Gypenoside LI induces G2/M and arrest apoptosis in A549 cells.
Gypenoside LI increases intracellular ROS level. Gypenoside LI suppressed migration of A549 cells.
Gypenoside LI could obviously suppress the expression of CDK1 protein rather than
CDK2 and CDK4 proteins.
Gypenoside LI inhibits cell proliferation and upregulates expression of miR-128-3p in melanoma cells.
Gypenoside LI (75 and 29.71 μg/mL) can induce intrinsic apoptosis along with S phase arrest. Gypenoside LI inhibited the colony formation ability of melanoma through inhibition of the Wnt/β-catenin signaling pathway.
Gypenoside LI induces PARP cleavage, increased the expression of cleaved caspase-9 and BID death agonist, and downregulates the expression of FLIP (long form) and BCl-2 in the A375 and SK-MEL-28 melanoma cells.
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