Dehydrojuncusol 产品活性：Dehydrojuncusol 是一种有效的丙型肝炎 (HCV) 病毒抑制剂，以丙型肝炎病毒 NS5A 为靶点，能够抑制带有抗 NS5A 直接作用抗病毒活性分子抗性突变的复制子的 RNA 复制。Dehydrojuncusol 可抑制 HCV 基因型 2a 的病毒感染 (EC50=1.35 μM)。 产品来源： https://www.medchemexpress.cn/dehydrojuncusol.html 研究领域：Anti-infection | Metabolic Enzyme/Protease 作用靶点：HCV | HCV Protease 来源：植物 | 其他科 结构分类：酚类 | 多酚类 | 结构分类 In Vitro: Dehydrojuncusol (Huh-7 cells were infected with HCV in cell culture; 0-9.4 μM; 48 hours) inhibits HCV infection in a dose-dependent manner. Dehydrojuncusol inhibits HCV infection in Primary human hepatocytes (PHH). The EC50 of dehydrojuncusol is 1.35?μM when added continuously, 8.21?μM when added during inoculation, and 1.53?μM when added postinoculation, confirming the major effect of the molecule at the postinoculation step. The toxicity of the compound on Huh-7 cells is also tested in parallel at different time points (24?h, 48?h, and 72?h). The results shows that the CC50 of Dehydrojuncusol Is approximately 75.6?μM, which is much higher than the active dose, yielding a selective index of 56. Dehydrojuncusol is able to inhibit RNA replication of two frequent daclatasvir-resistant mutants (L31M or Y93H in NS5A). Dehydrojuncusol inhibits HCV RNA replication. 相关产品：Resiquimod | Honokiol | Ribavirin | Deferiprone | U18666A | Artemisinin | Asunaprevir | AG-1478 | Myriocin | Grazoprevir | EIDD-1931 | Sofosbuvir | NIM811 | Simeprevir | RO8191 | Vesatolimod | BLT-1 | Mizoribine | GS-443902 trisodium | Elbasvir | Ledipasvir | Glecaprevir | Daclatasvir | Alisporivir | Cyclo(Phe-Pro) | Azvudine hydrochloride | Paritaprevir | Telaprevir | Boceprevir | Velpatasvir 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。