Dehydrocurdione 产品活性：Dehydrocurdione，一种 zedoary 衍生的倍半萜，在 RAW 264.7 巨噬细胞中诱导血红素加氧酶 (HO)-1，一种抗氧化酶。Dehydrocurdione 与 Keap1 相互作用，导致 Nrf2 易位，随后激活 HO-1 E2 增强子。Dehydrocurdione 抑制脂多糖诱导的 NO 释放，NO 是炎症的标志物。抗炎活性。 产品来源： https://www.medchemexpress.cn/dehydrocurdione.html 研究领域：NF-κB | Metabolic Enzyme/Protease | Immunology/Inflammation 作用靶点：Keap1-Nrf2 | Reactive Oxygen Species 来源：植物 | 姜科 | 莪术 结构分类：萜类 | 倍半萜 In Vitro: Dehydrocurdione (RAW 264.7 cells) concentration-dependently increases the HO-1 mRNA level for 3 hr and the protein level for 6 hr, and both effects reached significance at a concentration of 100 μM. Dehydrocurdione interacts with Keap, resulting in Nrf2 translocation followed by activation ofthe HO-1 E2 enhancer. In Vivo: Dehydrocurdione (P.o ;120 mg/kg, daily for 12 days) significantly reduces chronic adjuvant arthritis. Dehydrocurdione (200 mg/kg; p.o.; Sprague-Dawley rats) dose-dependently inhibits carrageenan-induced paw edema. 相关产品：Acetylcysteine | H2DCFDA | Deferoxamine mesylate | ML385 | MitoSOX Red | Elesclomol | Quercetin | L-Ascorbic acid | Resveratrol | Curcumin | 4-Octyl itaconate | Mito-TEMPO | Mitoquinone mesylate | Sulforaphane | L-Glutathione reduced | Luteolin | TBHQ | Trolox | Dimethyl fumarate | Zinc Protoporphyrin | FX-11 | Omaveloxolone | Diphenyleneiodonium chloride | Urolithin A | Bardoxolone methyl | Sodium dichloroacetate | Berberine chloride | TPEN | KI696 | α-Vitamin E 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。