耗材描述
Sanguisorbigenin
产品活性:Sanguisorbigenin 是一种天然抗菌剂,可抑制耐甲氧西林金黄色葡萄球菌 (MRSA)。
产品来源: https://www.medchemexpress.cn/sanguisorbigenin.html
研究领域:Anti-infection
作用靶点:Bacterial
来源:植物 | 蔷薇科 | 地榆
结构分类:萜类 | 三萜 | 结构分类
In Vitro: The minimal inhibitory concentration values of Sanguisorbigenin against six strains of S. aureus are in the range of 12.5-50 μg/mL.
The expression of blaR1, mecA and blaZ is significantly inhibited in MRSA in a dose-dependent manner when it is treated with sub-MIC (1.56-6.25 μg/mL) concentrations of Sanguisorbigenin. Sanguisorbigenin remarkably reduces the gene expression of mecA. Sanguisorbigenin has a potent antibacterial effect and could effectively reverse the sense of antibiotics by inhibiting the mecA expression and decrease PBP2a expression.
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