耗材描述
Pendulone
产品活性:Pendulone 是一种异黄烷醌,具有良好的抗疟原虫活性,IC50 为 7.0 µM。Pendulone 还具有抗利什曼原虫、抗菌和抗癌活性。
产品来源: https://www.medchemexpress.cn/pendulone.html
研究领域:Anti-infection
作用靶点:Parasite | Bacterial
来源:植物 | 其他科
结构分类:醌类 | 苯醌类 | 酚类 | 单酚类
In Vitro: Pendulone displays moderate antiproliferative activity against the A2780 human ovarian cancer cell line, with an IC50 value 19.6 µM.
Pendulone displays an IC50 value of 0.43 µg/mL, against L. donovani promastigotes. Pendulone also displays antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus (each IC50 of 1.44 µg/mL).
Pendulone exhibits moderate anticancer activity against human cancer cell lines (SK-MEL, KB, BT-549 and SK-OV-3) with IC50 values of 5.5 and 10.5 μg/mL. Pendulone also shows moderate cytotoxicities against monkey kidney fibroblasts (VERO) and pig kidney epithelial cells (LLC-PK11).
Pendulone shows strong inhibition on the effect of the cell cycle induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in Raji cells.
In Vivo: Pendulone shows potent anti-tumor-promoting activity for an in vivo two-stage carcinogenesis test of mouse skin using 7,12-dimethylbenz[a]-anthracene and TPA.
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