Boldine 产品活性：Boldine 是一种阿扑吗啡异喹啉生物碱，可从山鸡椒 (Litsea cubeba) 根中提取得到。Boldine 是一种口服有效的具抗氧化、抗炎、抗肿瘤剂，并能抑制破骨细胞生成。Boldine 通过调控 ERK, AKT 和 GSK-3β 诱导人膀胱癌细胞凋亡。Boldine 通过下调 OPG/RANKL/RANK 信号途径来改善骨破坏。可用于类风湿性关节炎研究。 产品来源： https://www.medchemexpress.cn/boldine.html 研究领域：NF-κB | Apoptosis 作用靶点：RANKL/RANK | Apoptosis 来源：植物 | 樟科 | 山鸡椒 结构分类：生物碱 | 异喹啉类生物碱 | 酚类 | 多酚类 | 结构分类 In Vitro: Boldine (10-500 μM, 24 h) inhibits the growth of bladder cancer cells in T24 patients[2]. Boldine (200-500 μM, 24 h) induces cycle arrest and apoptosis of bladder cancer cells in T24 by regulating ERK, AKT and GSK-3β. In Vivo: Boldine (50 mg/kg, p.o, for 7 days) attenuates Dextran Sulfate Sodium (DSS) -induced colitis in mice via p65-NF-κB and STAT3 signaling pathways. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Apoptosis Compound Library | Immunology/Inflammation Compound Library | NF-κB Signaling Compound Library | Natural Product Library | Anti-Aging Compound Library | Antioxidant Compound Library | Medicine Food Homology Compound Library | Phenols Library | Orally Active Compound Library | Traditional Chinese Medicine Active Compound Library | FDA Approved & Pharmacopeial Drug Library | Alkaloids Library | Food-Sourced Compound Library | Anti-Cancer Natural Product Library | Anti-inflammatory Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | Cell Death Library | Radioprotector Library | Bioactive Compound Library Max | MG-132 | Doxorubicin hydrochloride | Bafilomycin A1 | Tamoxifen | Y-27632 | LY294002 | Paclitaxel | Z-VAD-FMK | Acetylcysteine | Angiotensin II human | 2-Deoxy-D-glucose | Staurosporine | Actinomycin D | SB-431542 | 5-Fluorouracil | Bortezomib | Deferoxamine mesylate | Oxaliplatin | Trametinib | Sorafenib | Temozolomide | Gemcitabine | Decitabine | Mdivi-1 | Rotenone | Etoposide | Elesclomol | Ruxolitinib | Monomethyl auristatin E | DAPT 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。