4-Hydroxyisoleucine 产品活性：4-Hydroxyisoleucine 是可以从胡芦巴种子中分离得到的一种具有口服活性的氨基酸。4-Hydroxyisoleucine 具有促胰岛素和抗糖尿病的特性。 产品来源： https://www.medchemexpress.cn/4-hydroxyisoleucine.html 研究领域：Others 作用靶点：Others 来源：植物 | 豆科 | 胡卢巴 | 植物 | 其他科 结构分类：酮、醛、酸 | 结构分类 In Vitro: 4-Hydroxyisoleucine (20 μM, 6 h) decreases the level of iRhom2, TACE, TNF-α and MCP-1 in RAW264.7 macrophages and 3 T3-L1 adipocytes with LPS (HY-D1056) induction. 4-Hydroxyisoleucine (20 μM, 6 h) increases the product of M1 macrophage IL-6 and decreases the product of M2 macrophage IL-10 in the co-culture system with LPS (HY-D1056) stimulation. 4-Hydroxyisoleucine (0-25 μM, 16 h) increases glucose uptake and surface GLUT4myc level in L6-GLUT4myc myotubes in a concentration-dependent manner. 4-Hydroxyisoleucine (0-25 μM, 16 h) stimulates GLUT4myc translocation via PI-3-K/AKT-dependent mechanisms in L6-GLUT4myc myotubes. In Vivo: 4-Hydroxyisoleucine (50 mg/kg, p.o., daily, 8 weeks) inhibits the increase in serum glucose in the fructose-fed rat model of metabolic syndrome. 4-Hydroxyisoleucine (200 mg/kg, p.o., 8 weeks) improves dyslipidemia and reduces lipid ectopic accumulation in C57BL/6 mice. 4-Hydroxyisoleucine (200 mg/kg, p.o., 8 weeks) decreases the expression of proinflammatory cytokine (IL-6, PAI-1, IL-1β, NF-κB, TNF-α, and MCP-1) and the proportion of proinflammatory M1 macrophages in C57BL/6 mice. 4-Hydroxyisoleucine (50 mg/kg, i.g., daily, 14 days) restores high levels of lipids (cholesterol, HDL, LDL and triglycerides) and uric acid in type 1 diabetic rat to that of nondiabetic controls level. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Natural Product Library | Anti-diabetic Compound Library | Pyroptosis Compound Library | Orally Active Compound Library | Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | Bioactive Compound Library Max | Digitonin | 5-Ph-IAA | FLAG peptide | 3X FLAG peptide | TCEP hydrochloride | Monocrotaline | Tocofersolan | Pronase E (Activity ≥ 7000 U/g) | DPPH | DNase I, Bovine pancreas | NMDI14 | O-Propargyl-Puromycin | Human IgG1 kappa, Isotype Control | Phytohemagglutinin | Hyaluronidase | Biotinyl tyramide | MYLS22 | Pertussis Toxin | N,N-Dimethylformamide | Kifunensine | OVA Peptide (323-339) | L-Tryptophan | 6-Aminonicotinamide | Lauryl maltose neopentyl glycol | Alkyne-phenol | Potassium oxonate | OVA Peptide(257-264) TFA | CHAPS | Teriparatide 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。