耗材描述
Malvidin-3-galactoside chloride
产品活性:Malvidin-3-galactoside chloride 是一种花青素单体,可诱导肝细胞癌 (HCC) 细胞周期停滞和凋亡。Malvidin-3-galactoside chloride 抑制 ROS 的产生和积累。Malvidin-3-galactoside chloride 具有抗肿瘤功能。
产品来源: https://www.medchemexpress.cn/malvidin-3-galactoside-chloride.html
研究领域:Apoptosis | Metabolic Enzyme/Protease | Immunology/Inflammation | NF-κB
作用靶点:Apoptosis | Endogenous Metabolite | Reactive Oxygen Species
来源:植物 | 其他科
结构分类:黄酮类 | 花色素类 | 酚类 | 多酚类 | 结构分类
In Vitro: Malvidin-3-galactoside chloride (50, 100, 200 μg/mL; for 24, 48, 72 h) displays obvious cytotoxicity on Huh-7 cells and has no significant effect with 50 and 100 μg/mL for 48 h. Malvidin-3-galactoside chloride has a notable cytotoxic effect against Huh-7 cells at 72 h.
Malvidin-3-galactoside chloride (50-200 μg/mL) arrests the cells in the S phase, accompanied by the cells in the G1 phase decreased, and the cells in the S phase increased.
Malvidin-3-galactoside chloride (50-200 μg/mL; for 72 h) induces cell apoptosis in Huh-7 cells.
Malvidin-3-galactoside chloride (50-200 μg/mL; for 72 h) markedly increased the levels of caspase-3, cleaved-caspase-3 and cleaved-PARP in a dose-dependent manner.
Malvidin-3-galactoside chloride (50-200 μg/mL; for 12 h) inhibits the production and accumulation of ROS.
Malvidin-3-galactoside chloride (50-200 μg/mL; for 12 h) dramatically reduces the level of phosphorylation ERK (p-ERK) in a dose-dependent manner. Malvidin-3-galactoside chloride with 200 μg/mL markedly increases the phosphorylation level of p38 and JNK (p-p38 and p-JNK).
Malvidin-3-galactoside chloride (50-200 μg/mL; for 12 h) inhibits the migration and invasion in Huh-7 cells.
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