耗材描述
Ilexhainanoside D
产品活性:Ilexhainanoside D 是从 Ilex hainanensis Merr. 中提取的主要三萜皂苷,Ilexhainanoside D 和 Ilexsaponin A1 联合使用后具有抗炎的作用。
产品来源: https://www.medchemexpress.cn/ilexhainanoside-d.html
研究领域:Others
作用靶点:Others
来源:植物 | 冬青科 | 毛冬青
结构分类:萜类 | 三萜
In Vivo: The combination of Ilexhainanoside D and Ilexsaponin A (60, 120 or 240 mg/kg; for 8 weeks) treatment significantly reduces the severity of non-alcoholic fatty liver disease (NAFLD) induced by high-fat diet in a dose-dependent manner. The combination of Ilexhainanoside D and Ilexsaponin A treatment decreases the ratio of Firmicutes/Bacteroidetes, reduces the relative abundance of Desulfovibrio and increases the relative abundance of Akkermansia. The intestinal barrier is improved as evidenced by the upregulation of the expression of zonula occludens-1 (ZO-1) and occludin in the ileum. The combination of Ilexhainanoside D and Ilexsaponin A treatment reduces the entry of LPS into the circulation and decreases the hepatic gene expression levels of proinflammatory cytokines.
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