Derrone 产品活性：Derrone 是一种戊烯基异黄酮，是 Aurora 激酶抑制剂，其对 Aurora B 和 Aurora A 的 IC50 值分别为 6 和 22.3 μM。Derrone 显示出抗肿瘤活性。 产品来源： https://www.medchemexpress.cn/derrone.html 研究领域：Cell Cycle/DNA Damage | Epigenetics | Immunology/Inflammation | NF-κB | Metabolic Enzyme/Protease 作用靶点：Aurora Kinase | PERK | Reactive Oxygen Species 来源：植物 | 桑科 | 橙桑 结构分类：黄酮类 | 异黄酮 | 酚类 | 单酚类 In Vitro: Derrone (30-60 μM, 15 days) significantly inhibits the formation and growth of MCF7 tumor spheroids, with the tumor spheroid growth inhibition (% TGI) of 17.5% and 65.4% for 30 and 60 μM Derrone, respectively. Derrone shows the autophagic features, such as the conversion of LC3-I to LC3-II, the formation of autophagosome and the downregulation of SQSTM1/p62 (p62). Derrone induces autophagic cell death through intracellular ROS and sustained ERK phosphorylation in A549 cells. 相关产品：Acetylcysteine | H2DCFDA | Deferoxamine mesylate | MitoSOX Red | Elesclomol | Quercetin | L-Ascorbic acid | Mito-TEMPO | Mitoquinone mesylate | Sulforaphane | L-Glutathione reduced | Trolox | GSK2606414 | Alisertib | ISRIB (trans-isomer) | Dimethyl fumarate | Zinc Protoporphyrin | FX-11 | Diphenyleneiodonium chloride | Urolithin A | Sodium dichloroacetate | Berberine chloride | TPEN | GSK2656157 | α-Vitamin E | Ciprofloxacin | 2-Methoxyestradiol | Coenzyme Q10 | Tempol | GSK2795039 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。