Isodiospyrin 产品活性：Isodiospyrin 是一种天然二聚体萘醌，是一种人类 DNA 拓扑异构酶 I (topoisomerase I) (Topoisomerase) 抑制剂。Isodiospyrin 可以防止 DNA 松弛和人拓扑异构酶 I 的激酶活性。Isodiospyrin 具有抗癌、抗菌和抗真菌活性。 产品来源： https://www.medchemexpress.cn/isodiospyrin.html 研究领域：Cell Cycle/DNA Damage | Anti-infection 作用靶点：Topoisomerase | Bacterial | Fungal 来源：植物 | 其他科 | 美洲柿 结构分类：醌类 | 苯醌类 | 结构分类 In Vitro: Isodiospyrin (10-40 μM) does not induce human topoisomerase I (htopo I)-DNA covalent complexes. However, Isodiospyrin antagonizes Camptothecin-induced, htopo I-mediated DNA cleavage. Isodiospyrin binds htopo I but not DNA. Isodiospyrin exhibits strong inhibitory effect on the kinase activity of htopo I toward splicing factor 2/alternate splicing factor in the absence of DNA. Isodiospyrin against Gram-positive bacteria with MICs ranged from 0.78 to 50 μg/mL. While Isodiospyrin against Pseudomonas aeruginosa ATCC 15443 and S. typhi ranged from 50 to 100 μg/mL. The MIC for M. chelonae is between 6.25 and 25 μg/mL. Isodiospyrin (30 μM; 120-144 hours) shows 81.4 % growth inhibition of P. obscurans. The antifungal activity of Isodiospyrin at 30 μM against P. viticola is 57.7 %. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Anti-Infection Compound Library | Cell Cycle/DNA Damage Compound Library | Natural Product Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Antifungal Compound Library | Antibacterial Compound Library | Medicine Food Homology Compound Library | Traditional Chinese Medicine Active Compound Library | Anti-Lung Cancer Compound Library | Anti-Cancer Natural Product Library | Plant-Sourced Natural Product Library | Highly Selective Inhibitors Library | Inflammasomes related Compound Library | Multi-Target Compound Library | Bioactive Compound Library Max | Rapamycin | Ferrostatin-1 | Cycloheximide | Doxorubicin hydrochloride | Bafilomycin A1 | Dimethyl sulfoxide | Dexamethasone | Puromycin dihydrochloride | Staurosporine | Actinomycin D | Etoposide | G-418 disulfate | Nigericin sodium salt | 5-Azacytidine | Brefeldin A | CCCP | Estradiol | Exatecan mesylate | Ionomycin | Hygromycin B | Mitomycin C | Resveratrol | Tunicamycin | Everolimus | Doxycycline hyclate | Tacrolimus | SN-38 | Oligomycin 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。