Juglanin 产品活性：Juglanin 是一种可以从粗萹蓄中分离得到的黄酮类化合物。Juglanin 是一种 JNK 的激活剂，具有抗炎，抗氧化和抗肿瘤活性。Juglanin 能诱导人乳腺癌细胞的凋亡 (apoptosis) 和自噬 (autophagy)。 产品来源： https://www.medchemexpress.cn/Juglanin.html 研究领域：MAPK/ERK Pathway | Apoptosis | Autophagy 作用靶点：JNK | Apoptosis | Autophagy 来源：植物 | 其他科 结构分类：黄酮类 | 黄酮醇 | 酚类 | 多酚类 | 结构分类 In Vitro: Juglanin (0-40 μM, 24-48 h) inhibits the proliferation of breast cancer cell in a dose- and time-dependent manner and presents less cytotoxic against the normal cells. Juglanin (0-10 μM, 24 h) induces the G2/M phase arrest and Caspase-dependent apoptosis in MCF-7/SKBR3 cells. Juglanin (10 μM, 24 h) promotes ROS generation and enhances JNK activation in MCF-7/SKBR3 cells. Juglanin (40-160 μM, 24 h) inhibits inflammation and attenuates neuroinflammation in Lipopolysaccharides (LPS, HY-D1056)-treated AST cells. Juglanin (40 μM, 24 h) inhibits Sting expression in TGF-β1-incubated MRC-5 cells. In Vivo: Juglanin (10-20 mg/kg, i.p., daily, 7 days) inhibits growth of human breast cancer xenograft in a tumor-transplanted mouse model. Juglanin (10-30 mg/kg, i.p., 5 times weekly) ameliorates neuroinflammation-related memory impairment and neurodegeneration through impeding TLR4/NF-κB in C57BL6 male mice. Juglanin (80 mg/kg, i.g., daily, 21 days) protects against bleomycin (BLM, HY-108345)-induced lung injury by inhibiting fibrosis in C57BL/6 male mice. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Apoptosis Compound Library | Immunology/Inflammation Compound Library | MAPK Compound Library | Natural Product Library | Anti-Cancer Compound Library | Autophagy Compound Library | Glycoside Compound Library | Lipid Compound Library | Oxygen Sensing Compound Library | Medicine Food Homology Compound Library | Phenols Library | Traditional Chinese Medicine Active Compound Library | Flavonoids Library | Anti-Breast Cancer Compound Library | Transcription Factor-Targeted Library | Food-Sourced Compound Library | Anti-Cancer Natural Product Library | Anti-inflammatory Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | Human Metabolite Library | Osteogenesis Compound Library | Heterocyclic Compound Library | Pain-Related Compound Library | Cell Death Library | Bioactive Compound Library Max | MG-132 | Doxorubicin hydrochloride | Bafilomycin A1 | Tamoxifen | Y-27632 | LY294002 | Paclitaxel | Z-VAD-FMK | Acetylcysteine | Angiotensin II human | 2-Deoxy-D-glucose | Staurosporine | Actinomycin D | SB-431542 | 5-Fluorouracil | Bortezomib | Deferoxamine mesylate | Oxaliplatin | Trametinib | Sorafenib | Temozolomide | Gemcitabine | Decitabine | Mdivi-1 | Rotenone | Etoposide | Elesclomol | Ruxolitinib | Monomethyl auristatin E | DAPT 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。