Kazinol B 产品活性：Kazinol B 是一种带有二甲基吡喃环的异戊二烯化黄烷，是一氧化氮 (NO) 生成的抑制剂。Kazinol B 通过胰岛素-Akt 信号通路和 AMPK 激活增强葡萄糖摄取，从而改善胰岛素敏感性。Kazinol B 具有用于糖尿病研究的潜力。 产品来源： https://www.medchemexpress.cn/kazinol-b.html 研究领域：Immunology/Inflammation | PI3K/Akt/mTOR | Epigenetics 作用靶点：NO Synthase | Akt | AMPK 来源：植物 | 其他科 结构分类：酚类 | 多酚类 In Vitro: Kazinol B (2, 10 and 20 μM; 72 hours) shows no toxicity to adipocytes in 3T3-L1 cells. Kazinol B (2-20 μM; 72 hours) dose-dependently increases lipid accumulation by 2.4-fold (at 20 μM) treatment as compared with MDI-treated cells. Kazinol B (2-20 μM; 5 days) dose-dependently increases PPARγ and C/EBPα protein and mRNA levels in MDI-treated 3T3-L1 adipocytes. Kazinol B increases the mRNA level of adiponectin in a dose-dependent manner. Kazinol B (2-20 μM; 24 hours) increases the retained 2ʹNBDG-fluorescence in cells in a dose-dependent manner in differentiated 3T3-L1 adipocytes and C2C12 myoblasts. Kazinol B dependently increases the MDI-stimulated GLUT4 mRNA level up to 4.7-fold as compared with MDI-only treated cells. Kazinol B (10-20 μM; pre-treated for 1 h followed by 1 h insulin) dose-dependently increases insulin-dependent Akt phosphorylation. Kazinol B alone strongly induces Akt phosphorylation compared with untreated cells. Kazinol B also increased insulin-stimulated AMPK phosphorylation. Kazinol B (6.25, 12.5, 25, 50 μM; 18 hours) dose-dependently reduces amounts of iNOS protein in macrophages (RAW 264.7 cells) activated by LPS (1 ug/mL). 相关产品：Doxorubicin hydrochloride | Deferoxamine mesylate | Dorsomorphin | MK-2206 dihydrochloride | Metformin | AICAR | SC79 | Yoda 1 | Capivasertib | Afatinib | L-NAME hydrochloride | Mifepristone | Ipatasertib | A-769662 | Midostaurin | Chloramphenicol | Honokiol | L-Arginine | MK8722 | Bempedoic acid | Oridonin | Isoginkgetin | AKT inhibitor VIII | α-Linolenic acid | Artemisinin | GSK-690693 | Scutellarin | Ergothioneine 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。