耗材描述
Moracin C
产品活性:Moracin C,一种天然产物,是一种抗炎剂。Moracin C 抑制 LPS 激活的活性氧 (ROS) 和一氧化氮 (NO) 从细胞中释放。
产品来源: https://www.medchemexpress.cn/moracin-c.html
研究领域:Immunology/Inflammation | NF-κB | Metabolic Enzyme/Protease
作用靶点:Reactive Oxygen Species | COX
来源:植物 | 桑科
结构分类:酚类 | 多酚类 | 结构分类
In Vitro: Moracin C (1-50 μM, 24 h) inhibits LPS-activated reactive oxygen species (ROS) and nitric oxide (NO) release from RAW264.7 cells.
Moracin C (1-50 μM, 2 h) inhibits mRNA and protein expression of iNOS and COX-2 in RAW264.7 cells.
Moracin C (1-50 μM, 2 h) inhibits pro-inflammatory cytokine (IL-1β, IL-6 and TNF-α) productions in LPS-activated RAW 264.7 cells.
Moracin C (1-50 μM, 2 h) inhibits phosphorylation of p38, ERK and JNK in LPS-activated RAW 264.7 cells.
In Vivo: Moracin C (100 mg/kg, oral gavage, mice) was rapidly and well absorbed in the intestinal tract, and was highly distributed in the gastrointestinal tract, liver, kidneys, and lungs.
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