耗材描述
β-Amyrone
产品活性:β-Amyrone (β-Amyron) 是一种三萜类化合物,通过抑制 COX-2 的表达而发挥抗炎活性。β-Amyrone 具有抗真菌活性,及针对 Chikungunya 病毒的抗病毒活性。β-Amyrone 还可抑制 α-葡萄糖苷酶 (α-glucosidase ) 和乙酰胆碱酯酶 (AChE) 的活性。β-Amyrone 可用于炎症,感染,肥胖等疾病的研究。
产品来源: https://www.medchemexpress.cn/β-amyrone.html
研究领域:Anti-infection | Immunology/Inflammation | Cell Cycle/DNA Damage | Vitamin D Related/Nuclear Receptor | Metabolic Enzyme/Protease
作用靶点:Fungal | COX | PPAR
来源:植物 | 忍冬科 | 血满草
结构分类:萜类 | 三萜 | 结构分类
In Vitro: β-Amyrone (1.25-10 μg/mL, 24 h) inhibits on NO∙ production in LPS-stimulated J774 cells, with an IC50 value of 4.61 μg/mL, and has no obvious effect on cell viability.
β-Amyrone (10 μg/mL, 24 h) inhibits IL-6, IL-10 levels, and COX-2 expression in LPS-stimulated J774 cells.
β-Amyrone (0-235 μM, 7days) has antiviral activity in Vero cells against Chikungunya virus (CHIKV), with EC50 value of 86 uM.
β-Amyrone inhibits α-glucosidase, acetylcholinesterase (AChE) and fungal activity with IC50 values of 25 μM, 23 μM and 8 μg/mL, respectively.
In Vivo: β-Amyrone (local administration on ear, 0.1-0.6 mg/kg, a single dose) inhibits ear edema formation in phenol-induced edema mice.
相关产品:Natural Product Library Plus | Bioactive Compound Library Plus | Anti-Infection Compound Library | Cell Cycle/DNA Damage Compound Library | Immunology/Inflammation Compound Library | Metabolism/Protease Compound Library | Natural Product Library | Anti-Aging Compound Library | Antifungal Compound Library | Pyroptosis Compound Library | Traditional Chinese Medicine Active Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Obesity Compound Library | Transcription Factor-Targeted Library | Anti-Colorectal Cancer Compound Library | Antidepressant Compound Library | Anti-inflammatory Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | Anti-Prostate Cancer Compound Library | Nuclear Receptor Compound Library | Metabolic Enzyme Compound Library | Multi-Target Compound Library | Radioprotector Library | Bioactive Compound Library Max | Rapamycin | Ferrostatin-1 | Cycloheximide | Staurosporine | Retinoic acid | Rosiglitazone | Hygromycin B | Resveratrol | Tunicamycin | Oligomycin | GW9662 | Camptothecin | Acetaminophen | Indomethacin | EIPA | Celecoxib | Filipin complex | Aspirin | Amphotericin B | Pioglitazone | Calcimycin | GW6471 | Monensin sodium | Fenofibrate | Nystatin | Fisetin | Oxidopamine hydrobromide | Pirinixic acid | T0070907
品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物,我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物;10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域;设有专业的实验中心和严格的质控、验证体系;提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;产品的生物活性多经各国客户实验验证;Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;与世界各大制药公司及知名科研机构建立了长期的合作。