5-Heptadecylresorcinol 产品活性：5-Heptadecylresorcinol (AR-C17) 是一种酚类脂质成分，也是一种口服有效的线粒体保护剂。 5-Heptadecylresorcinol 通过 sirtuin3 信号通路改善线粒体功能，从而减轻内皮细胞损伤和细胞凋亡 (apoptosis)。5-Heptadecylresorcinol 诱导 sirtuin3 介导的自噬 (autophagy)。5-Heptadecylresorcinol 减少小鼠心脏主动脉根区的动脉粥样硬化斑块。5-Heptadecylresorcinol 可用于语预防动脉粥样硬化和肥胖的研究。 产品来源： https://www.medchemexpress.cn/5-heptadecylresorcinol.html 研究领域：Cell Cycle/DNA Damage | Epigenetics 作用靶点：Sirtuin 来源：植物 | 禾本科 | 黑麦 结构分类：酚类 | 多酚类 | 结构分类 In Vitro: 5-Heptadecylresorcinol (0, 0.5, 1, and 2 µM; 24 h) alleviates mitochondrial dysfunction through upregulation of SIRT3 in HUVECs. 5-Heptadecylresorcinol alleviates inflammatory conditioned medium (CM) induced adipocyte lipolysis and mitochondrial damage, accompanied by attenuated mitochondrial reactive oxygen species production and mitochondrial membrane depolarization. 5-Heptadecylresorcinol (5, 10 and 15 μM; 24 h) significantly prevents CM-induced adipocyte lipolysis by decreasing the release of glycerol in 3T3-L1 adipocytes. 5-Heptadecylresorcinol (5, 10 and 15 μM; 24 h) ameliorates mitochondrial dysfunction in adipocytes induced by CM. In Vivo: 5-Heptadecylresorcinol (30 mg/kg, 150 mg/kg; po daily for 16 weeks) improves the lipid metabolism in HFD-fed ApoE−/− mice. 5-Heptadecylresorcinol (30 mg/kg, 150 mg/kg; po daily for 16 weeks) increases the body weight of mouse, and alleviates adipose tissue macrophage infiltration and mitochondrial dysfunction. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Epigenetics Compound Library | Natural Product Library | Histone Modification Research Compound Library | Anti-Aging Compound Library | Antioxidant Compound Library | Lipid Compound Library | Oxygen Sensing Compound Library | Anti-Cardiovascular Disease Compound Library | Phenols Library | Orally Active Compound Library | Glutamine Metabolism Compound Library | Traditional Chinese Medicine Active Compound Library | Food-Sourced Compound Library | Plant-Sourced Natural Product Library | Human Metabolite Library | Metabolic Enzyme Compound Library | Radioprotector Library | Bioactive Compound Library Max | Nicotinamide | Resveratrol | Selisistat | Nicotinamide riboside chloride | 3-TYP | Fisetin | SRT 1720 | Suramin sodium salt | OSS_128167 | AGK2 | SRT 2104 | Sirtinol | UBCS039 | SIRT7 inhibitor 97491 | Thiomyristoyl | MC3482 | SirReal2 | Tenovin-6 | ADTL-SA1215 | Agrimol B | AK-7 | Cambinol | SRT 2183 | SRT 1460 | SIRT5 inhibitor 1 | SIRT6 activator 12q | CAY10602 | Ganoderic acid D | Perindopril erbumine 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。