Karanjin 产品活性：Karanjin 是一种具有口服活性的呋喃类黄酮，可从几种豆科植物中分离得到。Karanjin 具有明显的抗糖尿病、抗癌、抗炎、抗氧化、抗结肠炎、抗溃疡、抗阿尔茨海默病特性和多种驱虫/杀虫、杀螨特性，具有应用于相关研究的潜力。 产品来源： https://www.medchemexpress.cn/karanjin.html 研究领域：Epigenetics | PI3K/Akt/mTOR | Apoptosis | Metabolic Enzyme/Protease | NF-κB 作用靶点：AMPK | Apoptosis | Cytochrome P450 | Phosphatase | NF-κB 来源：植物 | 豆科 | 干花豆 结构分类：黄酮类 | 黄酮醇 | 结构分类 In Vitro: Karanjin (10-25 μM, 16 h) enhances glucose uptake in L6-GLUT4 myc cells through stimulates translocation of GLUT4 to plasma membrane-associated with activation of AMPK pathway and inhibits the activity of PTPase in a dose-dependent manner. Shows no significant effect on cell viability. Karanjin (4-8 μM, 72 h) blocks the cell cycle of A549 and HL-60 markedly as well as induces significant cell apoptosis. Karanjin (80, 160 μM, 30 min) decreases ROS level by inhibition of I-κB degradation resulting in restriction of NF-κB nuclear translocation in Hela cells. In Vivo: Karanjin (50, 100 mg/kg, p.o., 6 h) reduces the blood glucose level of Streptozotocin (HY-13753)-induced diabetic rats. Karanjin (20 mg/kg/d, p.o., 21 d) reduces joint injury and cartilage damage along with edema and erythema in the AIA model rats. Karanjin (10, 20 mg/kg/d, p.o., 14 d) significantly decreases serum ACP, ALP and TNFα levels in the AIA model rats . Karanjin (25 or 50 mg/kg/d, p.o. or i.g., 8 d) improved learning and memory in Diazepam-induced amnesia mice. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Apoptosis Compound Library | Epigenetics Compound Library | Immunology/Inflammation Compound Library | Metabolism/Protease Compound Library | NF-κB Signaling Compound Library | PI3K/Akt/mTOR Compound Library | Stem Cell Signaling Compound Library | Natural Product Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Antioxidant Compound Library | Differentiation Inducing Compound Library | Anti-diabetic Compound Library | Lipid Compound Library | Oxygen Sensing Compound Library | Endocrinology Compound Library | Glycolysis Compound Library | Pyroptosis Compound Library | Cytoskeleton Compound Library | Orally Active Compound Library | Traditional Chinese Medicine Active Compound Library | Flavonoids Library | Anti-Alzheimer's Disease Compound Library | Anti-Breast Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Phosphatase Inhibitor Library | Anti-Cancer Metabolism Compound Library | Neurodegenerative Disease-related Compound Library | Anti-Obesity Compound Library | Mitochondria-Targeted Compound Library | Transcription Factor-Targeted Library | Lipid Metabolism Compound Library | Glucose Metabolism Compound Library | Anti-Liver Cancer Compound Library | Anti-Cancer Natural Product Library | Antidepressant Compound Library | Anti-inflammatory Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | Human Metabolite Library | Anti-Prostate Cancer Compound Library | Anti-Pulmonary Fibrosis Compound Library | Cancer Stem Cells Compound Library | Pain-Related Compound Library | Metabolic Enzyme Compound Library | Cell Death Library | Anti-Hematopathy Compound Library | Anti-Ovarian Cancer Compound Library | Multi-Target Compound Library | Radioprotector Library | Bioactive Compound Library Max | MG-132 | Phorbol 12-myristate 13-acetate | Doxorubicin hydrochloride | Bafilomycin A1 | Tamoxifen | Y-27632 | LY294002 | Paclitaxel | Z-VAD-FMK | Acetylcysteine | Angiotensin II human | 2-Deoxy-D-glucose | Staurosporine | Actinomycin D | SB-431542 | 5-Fluorouracil | Bortezomib | Deferoxamine mesylate | Oxaliplatin | Trametinib | Sorafenib | Dorsomorphin | Temozolomide | Gemcitabine | Decitabine | Mdivi-1 | Rotenone | Etoposide | Elesclomol | Ruxolitinib 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。