Gigantol isomer-1 产品活性：Gigantol isomer-1 是一种来自石斛的联苄基化合物。Gigantol isomer-1 具有抗肿瘤活性。Gigantol isomer-1 是 Wnt/β-catenin 通路的抑制剂。 产品来源： https://www.medchemexpress.cn/Gigantol.html 研究领域：Stem Cell/Wnt 作用靶点：Wnt 来源：植物 | 兰科 | 石斛 结构分类：酚类 | 多酚类 | 结构分类 In Vitro: Gigantol isomer-1 decreases the level of phosphorylated LRP6 and cytosolic β-catenin in HEK293 cells. In breast cancer MDA-MB-231 and MDA-MB-468 cells, treatment with Gigantol isomer-1 reduces the level of phosphorylated LRP6. Gigantol isomer-1 significantly inhibits the proliferation and induces apoptosis of the HepG2 cells. Gigantol isomer-1 at concentrations of 1, 40 and 150 μM markedly decreases the cell viability by 11.7, 30.0 and 56.4% at 24 h and 21.1, 66.8 and 85.5% at 48 h, respectively. The IC50 value is 9.30 μM. In Vivo: LDD and Gigantol isomer-1 (25–100 mg/kg, p.o.) significantly increase the hot-plate latency in comparison to vehicle-treated mice and decreased carrageenaninduced inflammation in rats. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Stem Cell Signaling Compound Library | Wnt/Hedgehog/Notch Compound Library | Natural Product Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Differentiation Inducing Compound Library | Phenols Library | Cytoskeleton Compound Library | Traditional Chinese Medicine Active Compound Library | Neuroprotective Compound Library | Anti-Breast Cancer Compound Library | Targeted Diversity Library | Anti-Liver Cancer Compound Library | Anti-Colorectal Cancer Compound Library | Anti-Cancer Natural Product Library | Plant-Sourced Natural Product Library | Anti-Prostate Cancer Compound Library | Anti-Pulmonary Fibrosis Compound Library | Cancer Stem Cells Compound Library | Antihypertensive Compound Library | Extracellular Vesicles (EVs) Compound Library | Bioactive Compound Library Max | Anti-Gastric Cancer Compound Library | Anti-Fibrosis Compound Library | Laduviglusib | IWR-1 | IWP-2 | Monensin sodium | Wnt-C59 | MSAB | SKL2001 | Heparan Sulfate | Adavivint | Wogonin | Pyrvinium pamoate | Echinacoside | Salinomycin | BML-284 | NCB-0846 | iCRT3 | Ginkgetin | Foxy-5 TFA | FH535 | Platycodin D | SKI II | Box5 TFA | ETC-159 | iCRT 14 | Cardamonin | PNU-74654 | EMT inhibitor-1 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。