Agnuside 产品活性：Agnuside 能够用于哮喘，炎症，血管生成疾病的研究。Agnuside是一种口服有效的可以从黄荆中提取的化合物。 产品来源： https://www.medchemexpress.cn/agnuside.html 研究领域：Immunology/Inflammation | Apoptosis | Metabolic Enzyme/Protease 作用靶点：NO Synthase | COX | Caspase | HIF/HIF Prolyl-Hydroxylase | ASCT 来源：植物 | 其他科 结构分类：萜类 | 环烯醚萜 | 酚类 | 单酚类 | 结构分类 In Vitro: Agnuside (100 μM, 12-20 h) decreases the expression of iNOS, COX-2 and IL-8 proteins, and has anti-inflammatory effect in RAW264.7 and HT-29 cells stimulated by LPS (1 μg/mL/100 ng/mL) . Agnuside (0.1-2500 ng/mL, 20-96 h) promotes angiogenesis in HUVEC by promoting cell proliferation (EC50= 1.376 µg/mL) in a time- and dose-dependent manner. Agnuside (3 μM, 4 h) significantly reduces the levels of caspase-1, ASC, NLRP3, HIF-1α, IL-1β and IL-18 to inhibit inflammation in LPS (10 μg/ml) -stimulated fibroblast-like synoviocytes (FLSs). In Vivo: Agnuside (6.25 mg/kg; Oral administration; Single dose) reduces the levels of allergic inflammatory mediators in a dose-dependent manner and can inhibit allergic inflammation in Balb/C mice. Agnuside (6.25 mg/kg; Oral administration; Single dose) can inhibit autophagy in allergic asthma in Balb/C mice . Agnuside (6.25 mg/kg; Oral administration; single dose) can reduce synovitis and fibrosis in knee osteoarthritis (KOA) in MIA-induced KOA mice. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Apoptosis Compound Library | Epigenetics Compound Library | Immunology/Inflammation Compound Library | Metabolism/Protease Compound Library | Natural Product Library | Anti-Aging Compound Library | Reprogramming Compound Library | Glycoside Compound Library | Oxygen Sensing Compound Library | Anti-Cardiovascular Disease Compound Library | Terpenoids Library | Phenols Library | Pyroptosis Compound Library | Orally Active Compound Library | Glutamine Metabolism Compound Library | Traditional Chinese Medicine Active Compound Library | Neuroprotective Compound Library | Anti-Breast Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Angiogenesis-Related Compound Library | Transcription Factor-Targeted Library | Food-Sourced Compound Library | Anti-inflammatory Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | Cancer Stem Cells Compound Library | Mitochondrial Protection Compound Library | Metabolic Enzyme Compound Library | Protease Inhibitor Library | Membrane Protein-targeted Compound Library | Anti-Ovarian Cancer Compound Library | Multi-Target Compound Library | Radioprotector Library | Bioactive Compound Library Max | Anti-Fibrosis Compound Library | Z-VAD-FMK | Deferoxamine mesylate | Q-VD-OPh | DMOG | Belnacasan | Acetaminophen | Sulforaphane | PX-478 | Z-DEVD-FMK | Indomethacin | Roxadustat | L-NAME hydrochloride | Mifepristone | Emricasan | Tauroursodeoxycholate | Minocycline hydrochloride | EIPA | Celecoxib | Aspirin | Z-IETD-FMK | LW6 | Belzutifan | Ac-YVAD-cmk | Midostaurin | Chloramphenicol | Oxidopamine hydrobromide | L-Arginine | Deferiprone 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。