耗材描述
Deoxypodophyllotoxin
产品活性:Deoxypodophyllotoxin (DPT),鬼臼毒素的衍生物,是一种木酚素,从 Anthriscus sylvestris分离,具有强效抗有丝分裂和抗病毒特性。Deoxypodophyllotoxin 作为靶向微管的活性分子,不仅抗有丝分裂剂而且作为有效的血管生成抑制剂,在肿瘤学中具有重大影响。Deoxypodophyllotoxin 诱导细胞自噬 (autophagy) 和细胞凋亡 (apoptosis)。 Deoxypodophyllotoxin 引起 DRG 神经元细胞内 Ca2+ 浓度增加。
产品来源: https://www.medchemexpress.cn/deoxypodophyllotoxin.html
研究领域:Cell Cycle/DNA Damage | Cytoskeleton | Apoptosis | Autophagy
作用靶点:Microtubule/Tubulin | Apoptosis | Autophagy
来源:植物 | 菊科 | Centaurea ornata | 植物 | 伞形科 | 植物 | 其他科
结构分类:苯丙素类 | 木脂素 | 结构分类
In Vitro: Deoxypodophyllotoxin (25-75 nM; 6-48 hours) increases the percentage of early apoptotic cell population from 2.05 to 5.62 and 18.49% for 24 h and 48 h, respectively.
Deoxypodophyllotoxin (25-75 nM; 6-48 hours) treats SGC-7901 cells arrested in G2/M phase in time- and dose- dependent manners.
Deoxypodophyllotoxin (25-75 nM; 6-48 hours) results in a remarkably time- and dose-dependent decrease in Cdc2 and Cdc25C expression levels and increases cyclin B1 within 6h, decreases PARP, Bcl-2 and caspase-3 activity.
In Vivo: Deoxypodophyllotoxin (intravenously injected; 5, 10, and 20 mg/kg; 3 times a week; 28 days) suppresses the tumors in a dose-dependent manner, the growth of tumors is inhibited by 22.19%, 47.91% and 50.93% with DPT at 5, 10 and 20 mg/kg, respectively.
相关产品:Covalent Screening Library Plus | Natural Product Library Plus | Bioactive Compound Library Plus | Anti-Infection Compound Library | Apoptosis Compound Library | Cell Cycle/DNA Damage Compound Library | Natural Product Library | Autophagy Compound Library | Anti-Aging Compound Library | Covalent Screening Library | Anti-Cardiovascular Disease Compound Library | Cytoskeleton Compound Library | Traditional Chinese Medicine Active Compound Library | Anti-Lung Cancer Compound Library | Anti-Obesity Compound Library | Anti-Cancer Natural Product Library | Protein-protein Interaction Inhibitor Library | Plant-Sourced Natural Product Library | Cell Death Library | Bioactive Compound Library Max | MG-132 | Doxorubicin hydrochloride | Bafilomycin A1 | Tamoxifen | Y-27632 | LY294002 | Paclitaxel | Z-VAD-FMK | Acetylcysteine | Angiotensin II human | 2-Deoxy-D-glucose | Staurosporine | Actinomycin D | SB-431542 | 5-Fluorouracil | Bortezomib | Deferoxamine mesylate | Oxaliplatin | Trametinib | Sorafenib | Temozolomide | Gemcitabine | Decitabine | Mdivi-1 | Rotenone | Etoposide | Elesclomol | Ruxolitinib | Monomethyl auristatin E | DAPT
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