Desoxyrhaponticin 产品活性：Desoxyrhaponticin 是一种口服有效的脂肪酸合成酶 (FASN) 抑制剂，对人类癌细胞具有凋亡作用。Desoxyrhaponticin 还是葡萄糖摄取抑制剂，可能改善糖尿病动物的口服葡萄糖耐量，具有抗糖尿病作用。 产品来源： https://www.medchemexpress.cn/desoxyrhaponticin.html 研究领域：Metabolic Enzyme/Protease | Apoptosis 作用靶点：Fatty Acid Synthase (FASN) | Apoptosis 来源：植物 | 蓼科 | 波叶大黄 | 植物 | 蓼科 | 鸡爪大黄 结构分类：酚类 | 单酚类 | 二苯乙烯类 | 结构分类 In Vitro: The IC50s values for inhibition of renal membrane vesicle uptake in normal rats and diabetic rats were 118.8 and 115.7 μM, respectively. Desoxyrhaponticin effectively controls hyperglycemia by inhibiting glucose transport in the small intestine and inhibiting glucose reabsorption in the kidneys.Desoxyrhaponticin inhibits glucose uptake in rabbit intestinal mesangial vesicles and rat everted intestinal cuffs with IC50s of 148.3 and 30.9 μMs, respectively.Desoxyrhaponticin (500 μM) inhibits glucose uptake into rabbit intestinal brush-border membrane vesicles, IC50=30.9 μM. In Vivo: Desoxyrhaponticin (150, 300 mg/kg; po; single dose before the glucose loading) inhibits intestinal and renal glucose transport in normal and diabetic rats, and reduces postprandial hyperglycemia in diabetic rat. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Apoptosis Compound Library | Metabolism/Protease Compound Library | Natural Product Library | Anti-Cancer Compound Library | Anti-diabetic Compound Library | Glycoside Compound Library | Phenols Library | Orally Active Compound Library | Traditional Chinese Medicine Active Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Obesity Compound Library | Lipid Metabolism Compound Library | Anti-Cancer Natural Product Library | Plant-Sourced Natural Product Library | Human Metabolite Library | Metabolic Enzyme Compound Library | Cell Death Library | Bioactive Compound Library Max | MG-132 | Doxorubicin hydrochloride | Bafilomycin A1 | Tamoxifen | Y-27632 | LY294002 | Paclitaxel | Z-VAD-FMK | Acetylcysteine | Angiotensin II human | 2-Deoxy-D-glucose | Staurosporine | Actinomycin D | SB-431542 | 5-Fluorouracil | Bortezomib | Deferoxamine mesylate | Oxaliplatin | Trametinib | Sorafenib | Temozolomide | Gemcitabine | Decitabine | Mdivi-1 | Rotenone | Etoposide | Elesclomol | Ruxolitinib | Monomethyl auristatin E | DAPT 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。