耗材描述
Aloesin
产品活性:Aloesin (Aloeresin) 是一种 tyrosinase 抑制剂,并显示出抗炎活性、紫外线保护和抗细菌作用。Aloesin 能诱导细胞凋亡,可用于卵巢癌研究。
产品来源: https://www.medchemexpress.cn/aloesin.html
研究领域:Metabolic Enzyme/Protease | Apoptosis
作用靶点:Tyrosinase | Apoptosis
来源:植物 | 百合科 | 芦荟
结构分类:酚类 | 单酚类 | 酮、醛、酸
In Vitro: Aloesin (0-40 μM, 24, 48, and 72 h) inhibits ovarian cancer cell growth in a dose- and time-dependent manner.
Aloesin (0-10 μM; 48 h) arrest the cell cycle at S-phase in a dose-dependent manner in SKOV3 cells.
Aloesin (0-10 μM; 48 h) promotes cell apoptosis in SKOV3 cells.
Aloesin (0-10 μM; 48 h) inhibits the phosphorylation of the MAPK signaling pathway.
In Vivo: Aloesin (injection; 20 mg/kg or 40 mg/kg; once daily; 7 w) inhibits tumor growth in a Xenograft model of ovarian cancer.
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