24-Hydroxycholesterol 产品活性：24-Hydroxycholesterol 是一种天然的固醇类物质，是n-甲基-d-天门冬氨酸受体 (NMDA) 和转录因子 LXR 的激活剂。 产品来源： https://www.medchemexpress.cn/24-Hydroxycholesterol.html 研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling | Metabolic Enzyme/Protease | Vitamin D Related/Nuclear Receptor 作用靶点：iGluR | LXR 结构分类：甾体类 | 结构分类 In Vitro: 24S-hydroxycholesterol oxysterol-generating enzyme Cyp46a1 is overexpressed during the angiogenic switch in rat insulin promoter 1-T-antigen 2 (RIP1-Tag2) pNET formation. In Vivo: Hypoxia inducible factor-1a (HIF-1α) controls the overexpression of the enzyme Cyp46a1, which generates the oxysterol 24-hydroxycholesterol in a pancreatic neuroendocrine tumor (pNET) model commonly used to study neoangiogenesis. The activation of the HIF-1α-24S-HC axis ultimately leads to the induction of the angiogenic switch through the positioning of proangiogenic neutrophils in proximity to Cyp46a1+ islets. 24-hydroxycholesterol levels are increased at 2-4 months in the untreated 5XFAD mouse brain and then became similar to those in the B6SJL mouse brain. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Membrane Transporter/Ion Channel Compound Library | Metabolism/Protease Compound Library | Neuronal Signaling Compound Library | Natural Product Library | Lipid Compound Library | Neurotransmitter Receptor Compound Library | Lipid Metabolism Compound Library | Human Metabolite Library | Nuclear Receptor Compound Library | Metabolic Enzyme Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Animal-Sourced Natural Product Library | Ion Channel Compound Library | Allosteric Modulators (AMs) Compound Library | Multi-Target Compound Library | Bioactive Compound Library Max | Corticosterone | Dizocilpine maleate | D-AP5 | NMDA | T0901317 | L-Glutamic acid | GW3965 hydrochloride | Evans Blue | GSK2033 | CNQX | Kynurenic acid | Glycine | 27-Hydroxycholesterol | L-Phenylalanine | NBQX | Quinolinic acid | Cycloleucine | Ifenprodil tartrate | Memantine hydrochloride | D-Cycloserine | SR9243 | LXR-623 | DNQX | Ro 25-6981 Maleate | (-)-Huperzine A | Naspm trihydrochloride | Ibotenic acid | SR9238 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。