Kainic acid 产品活性：Kainic acid 是一种有效的兴奋性毒性剂。Kainic acid 也是离子型谷氨酸受体亚型的激动剂。Kainic acid 诱发癫痫发作。 产品来源： https://www.medchemexpress.cn/Kainic_acid.html 研究领域：Membrane Transporter/Ion Channel 作用靶点：EAAT 来源：植物 | 其他科 结构分类：生物碱 | 吡咯类生物碱 | 结构分类 In Vivo: Kainic acid (5 mg/kg; i.p.; hourly at least 3 h until status epilepticus) induces seizures in rats.The kainic acid induced seizures model is a good tool to study temporal lobe epilepsy. The model can be reproduced in a variety of species through either systemic, intrahippocampal or intra-amygdaloid administrations. The systemic Kainic acid administration induced model is similar with human temporal lobe epilepsy (TLE). Kainic acid (5 nmoles, injections into the neostriatum, substantia nigra or cerebellum) shows that more than half of the compound disappeared from the injection site and the brain by 1/2 hour post injection, and less than radioactivity of 7 pmol/mg of tissue were found in other areas. Induction of epilepsy model Background Kainic acid, an analog of L-glutamate and an ionotropic KA receptor agonist, can damage hippocampal pyramidal neurons. Specific Mmodeling Methods Mice: C57BL/6J • male • 7 weeks old • 22 g body weight Administration: 10 μg in 5 μL • i.c.v. Note (1) The right lateral brain ventricle is localized with a stereotactic instrument. (2) After the operation, skin was sutured, and keep the mice under a warming place until they wake up. (3) 48 hours after lateral ventricle injection, the mice are anaesthetized using Isoflurane and then sequentially intracardially perfused with saline and PFA (4%, 30 mL). Rapidly remove The mouse brain processed for paraffin embedding or frozen sections. Modeling Indicators Electroencephalogram (EEG) recording: Had higher local maximal amplitude and reduced spike frequency compared to the control group. Histology analysis: Showed Triangulated pyknotic nuclei and cytoplasmic shrinkage in the hippocampal neuron, and induced neuronal loss. 同类产品: 拮抗产品:Sitagliptin (HY-13749) Induction of epilepsy model Background Kainic acid can bind to NMDA receptors which are abundant in neurons in the cornu ammonus of the hippocampus, amygdala, and pyriform cortex, and leading to variable levels of neuronal death in these regions. Specific Mmodeling Methods Rat: Sprague-Dawley rats • male Administration: 10 mg/kg • i.p. • a single dose Note (1) Seizures occurres approximately 45 min after injection, typically lasted 2-3 hr. (2) Kainic acid-treated animals may die during an acute period of intoxication, it's suggested to increase the number of animals per group. (3) 72 hours later, the rats are anesthetized and immediately perfused transcardially with 50 mL 0.9% saline followed by 500 mL 0.1 m neutral phosphate-buffered formaldehyde (4%). And remove the brain and postfixed at 4°C overnight in the same fixative and dehydrated, embedded in paraffin, and cut into serial 6-μm-thick coronal sections at the level of the dorsal hippocampus. Modeling Indicators behavioral changes: Exhibited immobility and rigid postures firstly, followed by repetitive head nodding, ‘wet dog shakes’, and subsequent rearing and falling. Eventually, the rats developed generalized tonic–clonic seizures with continuous convulsions, lasting for several hours. Histology analysis: Resulted in a loss of pyramidal neurons in fields CA1 and CA3 of the hippocampus. Increaseed the size, arborization, and stainability of GFAP-immunoreactive cells. 同类产品: 拮抗产品:Melatonin (HY-B0075) 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Membrane Transporter/Ion Channel Compound Library | Natural Product Library | CNS-Penetrant Compound Library | Peptidomimetic Library | Traditional Chinese Medicine Active Compound Library | Alkaloids Library | Plant-Sourced Natural Product Library | Human Metabolite Library | Bioactive Compound Library Max | Evans Blue | DL-TBOA | LDN-212320 | UCPH-101 | WAY-213613 hydrochloride | GT 949 | TFB-TBOA | Dihydrokainic acid | SN05 | SN40 | EAAT2 activator 1 | UCPH-102 | (±)-HIP-A | (±)-HIP-B | (±)-threo-3-Methylglutamic acid | cis-α-(Carboxycyclopropyl)glycine | DA-023 | L-threo-3-Hydroxyaspartic acid | NA-014 | TAOA AM Ester trimethyl lock 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。