耗材描述
Aclacinomycin A hydrochloride
产品活性:Aclacinomycin A (Aclarubicin) hydrochloride 是一种蒽环类抗肿瘤的抗生素 (antibiotic)。Aclacinomycin A hydrochloride 是拓扑异构酶 (topoisomerase) I 和 II 的抑制剂。Aclacinomycin A hydrochloride 可抑制核酸的合成,特别是 RNA 的合成。Aclacinomycin A hydrochloride 可能抑制 26S 蛋白酶复合体以及泛素-ATP 依赖性蛋白水解。
产品来源: https://www.medchemexpress.cn/Aclacinomycin_A_hydrochloride.html
研究领域:Cell Cycle/DNA Damage | Metabolic Enzyme/Protease | Anti-infection
作用靶点:Topoisomerase | DNA/RNA Synthesis | Proteasome | Antibiotic
结构分类:醌类 | 蒽醌类 | 酚类 | 多酚类 | 结构分类
In Vitro: Aclacinomycin A (0-120 μM, 30 min) inhibits the ubiquitin-ATP-dependent proteolytic activity of rabbit reticulocytes in a dose-dependent manner, with an IC50 of 52 μM. But it does not inhibit the ubiquitination.
Aclacinomycin A inhibits ubiquitin-ATP-dependent proteolysis after the conjugation of ubiquitin to proteins.
Aclacinomycin A (0-2.4 μM, 3 h) inhibits the topo II catalytic activity.
Aclacinomycin A (0-1.8 μM, 3 h) has negative effect on the proliferative rate of V79 and irs-2 cells.
Aclacinomycin A emits fluorescence and that human-cervical cancer HeLa cells exposed to Aclacinomycin A exhibits bright fluorescence signals in the cytoplasm when fluorescence microscopy was performed using the red filter (excitation 530-550 nm/emission 575 nm).
In Vivo: Aclacinomycin A (0.75-6 mg/kg, IP, daily) dose-dependently exhibits tumor growth in mice-based Leukemia P-388 model.
Aclacinomycin A (0.6-20 mg/kg, Orally, daily) exhibits an antitumor effect on leukemia L-1210.
Aclacinomycin A is very well absorbed in mice, rats, and dogs after its oral administration. The oral LD50 (76.5 mg/kg) is about twice the iv LD50 (35.6 mg/kg) in mice.
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