Tomatidine hydrochloride 产品活性：Tomatidine hydrochloride 通过阻断 NF-κB 和 JNK 信号发挥抗炎作用。Tomatidine hydrochloride 激活哺乳动物细胞或秀丽隐杆线虫中的自噬 (autophagy)。 产品来源： https://www.medchemexpress.cn/Tomatidine_hydrochloride.html 研究领域：NF-κB | MAPK/ERK Pathway | Autophagy | Metabolic Enzyme/Protease 作用靶点：NF-κB | JNK | Autophagy | Endogenous Metabolite 来源：植物 | 茄科 | 番茄 结构分类：甾体类 In Vitro: Tomatidine decreases inducible NO synthase and COX-2 expression through suppression of I-κBα phosphorylation, NF-κB nuclear translocation and JNK activation, which in turn inhibits c-jun phosphorylation and Oct-2 expression. Tomatidine, solasodine and diosgenin (40 μM) show 66%, 22% and 41% inhibition of nitrite production, respectively. The iNOS protein is barely detectable in unstimulated cells but markedly increases after LPS treatment, and Tomatidine causes dose-dependent inhibition of LPS-induced iNOS expression. p65 is the major component of NF-κB in LPS-stimulated macrophages, the effect of Tomatidine on p65 DNA-binding activity is determined. In the presence of Tomatidine at 10-40 μM, the binding activity of NF-κB is suppressed in a dose-dependent manner. Tomatidine inhibits the phosphorylation of I-κB, blocks the I-κB production, and furthermore suppresses p65 NF-κB translocation to the nucleus and modulated binding activity. 相关产品：Covalent Screening Library Plus | Natural Product Library Plus | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Kinase Inhibitor Library | MAPK Compound Library | Metabolism/Protease Compound Library | NF-κB Signaling Compound Library | Stem Cell Signaling Compound Library | Natural Product Library | Autophagy Compound Library | Anti-Aging Compound Library | Covalent Screening Library | Antioxidant Compound Library | Differentiation Inducing Compound Library | Reprogramming Compound Library | Oxygen Sensing Compound Library | Anti-Cardiovascular Disease Compound Library | Pyroptosis Compound Library | Traditional Chinese Medicine Active Compound Library | Anti-Breast Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Parkinson's Disease Compound Library | Anti-Obesity Compound Library | Transcription Factor-Targeted Library | Food-Sourced Compound Library | Anti-Liver Cancer Compound Library | Antidepressant Compound Library | Anti-inflammatory Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | Human Metabolite Library | Anti-Prostate Cancer Compound Library | Anti-Pulmonary Fibrosis Compound Library | Anti-Aging Natural Product Library | Cancer Stem Cells Compound Library | Pain-Related Compound Library | Highly Selective Inhibitors Library | Highly Selective Activators Library | Cell Death Library | Serine/Threonine Kinase Inhibitor Library | Anti-Hematopathy Compound Library | Anti-Ovarian Cancer Compound Library | Multi-Target Compound Library | Radioprotector Library | Bioactive Compound Library Max | Rapamycin | Phorbol 12-myristate 13-acetate | 3-Methyladenine | Acetylcysteine | 5-Fluorouracil | Bortezomib | ATP | Retinoic acid | Hydrocortisone | SP600125 | Estradiol | BAY 11-7082 | Nicotinamide | Prostaglandin E2 | AICAR | Palmitic acid | Docetaxel | Isoprenaline hydrochloride | L-Ascorbic acid | Cytarabine | Melatonin | Calcitriol | Capsaicin | TAK-243 | Arachidonic acid | Valproic acid | Oleic acid | β-Nicotinamide mononucleotide | Acetaminophen | Anisomycin 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。