Kavain 产品活性：Kavain是一类从 Piper methysticum 中分离出来的卡瓦酸内酯，对动物和人类具有抗焦虑作用。Kavain 可以正调控 GABAA 受体。 产品来源： https://www.medchemexpress.cn/kavain.html 研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling 作用靶点：GABA Receptor 来源：植物 | 胡椒科 | Piper methysticum G.Forst. 结构分类：其他类 In Vitro: Two-electrode voltage clamp technique is used to characterize the functional properties of the major anxiolytic kavalactone, Kavain at human recombinant α1β2, β2γ2L, αxβ2γ2L, α1βxγ2L and α4β2δ γ-Aminobutyric acid type A receptors (GABAARs) expressed in Xenopus oocytes. Kavain positively modulates all receptors regardless of the subunit composition, but the degree of enhancement is greater at α4β2δ than at α1β2γ2L GABAARs. The modulatory effect of Kkavain is unaffected by flumazenil, indicating that Kavain does not enhance GABAARs via the classical benzodiazepine binding site.. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Membrane Transporter/Ion Channel Compound Library | Neuronal Signaling Compound Library | Natural Product Library | Medicine Food Homology Compound Library | Neurotransmitter Receptor Compound Library | Traditional Chinese Medicine Active Compound Library | Anti-Alzheimer's Disease Compound Library | Neuroprotective Compound Library | Anti-Parkinson's Disease Compound Library | Neurodegenerative Disease-related Compound Library | Antidepressant Compound Library | Plant-Sourced Natural Product Library | GABA Receptor Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Ion Channel Compound Library | Bioactive Compound Library Max | Bicuculline | γ-Aminobutyric acid | Picrotoxin | Aminooxyacetic acid hemihydrochloride | Propofol | Riluzole | Furosemide | Gabazine | Baclofen | Amentoflavone | Vigabatrin | CGP52432 | Flumazenil | Methionine | Jujuboside A | L-Cycloserine | Etiocholanolone | THIP | Topiramate | Broflanilide | Tiagabine hydrochloride | Muscimol | Clomethiazole | (S)-SNAP5114 | Dihydroergotoxine mesylate | Emamectin Benzoate | Ginkgolide A 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。