Withaferin A 产品活性：Withaferin A 是从睡茄中分离到的甾体内酯，可以抑制 NF-kB 的活性，靶作用于波形蛋白 (vimentin)，具有抗炎，抗肿瘤等功效。Withaferin A 是内皮蛋白 C 受体 (EPCR) 脱落的抑制剂。 产品来源： https://www.medchemexpress.cn/Withaferin_A.html 研究领域：NF-κB | Apoptosis 作用靶点：NF-κB | Ferroptosis 来源：植物 | 茄科 | 睡茄 | 植物 | 其他科 结构分类：甾体类 | 结构分类 In Vitro: Withaferin A has antiinflammatory activity, and potently inhibits NF-kB activation by preventing the TNF-induced activation of Ik-B kinase beta via a thioalkylation-sensitive redox mechanism. Withaferin A also has anticancer activity. Withaferin A targets the IF protein vimentin, causes aggregation of vimentin filaments in bovine aortic endothelial cells (BAECs) at 3 μM, and induces vimentin fragmentation in endothelial cells at 10 μM. Withaferin A (0.5, 1.5 μM) alone or incombination with cisplatin (CIS) dose-dependently reduces tumorigenic potential of ALDH1 positive cancer stem cells (CSCs). In Vivo: Withaferin A (2 mg/kg, i.p.) shows potent angiogenesis inhibitory activity via vimentin in mice. Withaferin A (2 mg/kg) combined with cisplatin (CIS) regulates the expression of ALDH1 marker, and downregulates the expression of securin in tumors collected from mice. 相关产品：Covalent Screening Library Plus | Natural Product Library Plus | Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Apoptosis Compound Library | Immunology/Inflammation Compound Library | NF-κB Signaling Compound Library | Stem Cell Signaling Compound Library | Natural Product Library | Anti-Cancer Compound Library | Clinical Compound Library | Anti-Aging Compound Library | Drug Repurposing Compound Library | Covalent Screening Library | Antioxidant Compound Library | Differentiation Inducing Compound Library | Lipid Compound Library | Oxygen Sensing Compound Library | Ferroptosis Compound Library | Medicine Food Homology Compound Library | Pyroptosis Compound Library | Traditional Chinese Medicine Active Compound Library | Anti-Breast Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Obesity Compound Library | Transcription Factor-Targeted Library | Anti-Liver Cancer Compound Library | Anti-Cancer Natural Product Library | Antidepressant Compound Library | Anti-inflammatory Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | Human Metabolite Library | Anti-Prostate Cancer Compound Library | Cancer Stem Cells Compound Library | Pain-Related Compound Library | Cysteine Targeted Covalent Library | Cell Death Library | Anti-Hematopathy Compound Library | Anti-Ovarian Cancer Compound Library | Radioprotector Library | Bioactive Compound Library Max | Ferrostatin-1 | Phorbol 12-myristate 13-acetate | Erastin | Cisplatin | Cycloheximide | RSL3 | Acetylcysteine | Bortezomib | ML385 | Sorafenib | Necrostatin-1 | SP600125 | BAY 11-7082 | Rosiglitazone | Liproxstatin-1 | Curcumin | Simvastatin | TAK-243 | Acetaminophen | Hemin | JSH-23 | L-Glutathione reduced | TBHQ | Trolox | Roxadustat | Lapatinib | Lovastatin | Shikonin | Sulfasalazine | NADPH tetrasodium salt 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。