Higenamine hydrochloride 产品活性：Higenamine hydrochloride 是一种可以从乌头毒草中分离得到的选择性的 LSD1 抑制剂 (IC50=1.47 μM)。Higenamine hydrochloride 具有抗炎、抗菌活性。Higenamine (Norcoclaurine) 能通过 ROS 介导的 PI3K/Akt 信号通路来减弱 IL-1β 引起的凋亡。Higenamine hydrochloride 能保护脑细胞免受缺氧损伤。Higenamine 能够通过 SMAD2/3 途径促进骨质疏松症的骨形成。Higenamine hydrochloride 可以用于癌症、炎症、心肾综合征等疾病的研究。 产品来源： https://www.medchemexpress.cn/higenamine-hydrochloride.html 研究领域：Apoptosis | Protein Tyrosine Kinase/RTK 作用靶点：MDM-2/p53 | ROS Kinase | Apoptosis 来源：植物 | 樟科 | 乌药 结构分类：生物碱 | 异喹啉类生物碱 | 酚类 | 多酚类 | 结构分类 In Vitro: Higenamine hydrochloride (3-100 μM; 72 h) can inhibit the differentiation of MV4-11 and MOLM-13 cells by inhibiting the activity of LSD1. Higenamine hydrochloride (1-100μM; 8 h) can enhance the activity of HO-1 in C6 cells and protect brain cells from cell hypoxia damage . Higenamine hydrochloride (10-50 μM; 8 h) can inhibit apoptosis in C6 cells. Higenamine hydrochloride (10-40 μM; 24 h) can inhibit the production of IL-1β-induced ROS and activate the ROS-mediated PI3K/Akt signaling pathway, which has anti-apoptotic activity in HNPCs. Higenamine hydrochloride (0.08-250 μM; 0.5-24 h) promotes phosphorylation of SMAD2/3 in a time- and dose-dependent manner in BMSCs. In Vivo: Higenamine hydrochloride (10 mg/kg; Intraperitoneal injection; Single dose) can significantly reduce the inflammation and infarct size of cerebral ischemic injury caused by middle cerebral artery occlusion (MCAO) in Sprague-Dawley rats. Higenamine hydrochloride (0.5-4.5 mg/kg; Single dose) improves cardiac and renal function in rats with cardio-renal syndrome (CRS) and alleviates cardiac and renal fibrosis by targeting ASK1/MAPK (ERK, P38)/NF-kB signaling pathway in Sprague-Dawley rats. Higenamine hydrochloride (20 mg/kg-30 mg/kg; Intraperitoneal injection; Once daily for 60 days) promotes bone formation and prevents accelerated bone loss in SAMP6 mice. 相关产品：Natural Product Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Anti-Infection Compound Library | Apoptosis Compound Library | Kinase Inhibitor Library | Protein Tyrosine Kinase Compound Library | Natural Product Library | Anti-Cancer Compound Library | Clinical Compound Library | Autophagy Compound Library | Anti-Aging Compound Library | Anti-Cardiovascular Disease Compound Library | Endocrinology Compound Library | Antibacterial Compound Library | Ferroptosis Compound Library | Medicine Food Homology Compound Library | Phenols Library | Pyroptosis Compound Library | Glutamine Metabolism Compound Library | Traditional Chinese Medicine Active Compound Library | Alkaloids Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Transcription Factor-Targeted Library | Anti-Cancer Natural Product Library | Antidepressant Compound Library | Plant-Sourced Natural Product Library | Human Metabolite Library | Non-steroidal Anti-Inflammatory Compound Library | Osteogenesis Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Highly Selective Inhibitors Library | Highly Selective Activators Library | Cell Death Library | Anti-Hematopathy Compound Library | Multi-Target Compound Library | Bioactive Compound Library Max | MG-132 | Doxorubicin hydrochloride | Bafilomycin A1 | Tamoxifen | Y-27632 | LY294002 | Paclitaxel | Z-VAD-FMK | Acetylcysteine | Angiotensin II human | 2-Deoxy-D-glucose | Staurosporine | Actinomycin D | SB-431542 | 5-Fluorouracil | Bortezomib | Deferoxamine mesylate | Oxaliplatin | Trametinib | Sorafenib | Temozolomide | Gemcitabine | Decitabine | Mdivi-1 | Rotenone | Etoposide | Elesclomol | Ruxolitinib | Monomethyl auristatin E | DAPT 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。