Hispidulin 产品活性：Hispidulin是具有广泛生物活性的天然黄酮。 Hispidulin是Pim-1的抑制剂，IC50值为2.71 μM。 产品来源： https://www.medchemexpress.cn/Hispidulin.html 研究领域：JAK/STAT Signaling 作用靶点：Pim 来源：植物 | 菊科 | 甜叶菊 | 植物 | 唇形科 结构分类：黄酮类 | 黄酮 | 酚类 | 多酚类 | 结构分类 In Vitro: Hispidulin induces cell death in a dose- and time-dependent manner in HepG2 cells. Hispidulin induces apoptosis through mitochondrial dysfunction, which is characterized by decreased Bcl-2/Bax ratio, disrupted mitochondrial membrane potential and increased release of cytochrome C and activated capase-3. In Vivo: Hispidulin shows significant inhibitory effect on mice tumor size. Hispidulin treatment effectively prevents ovariectomy-induced body weight loss and attenuates ovariectomy-induced bone loss. Hispidulin treatment also decreases trabecular spacing in ovariectomy mice. Intraperitoneally administering hispidulin(10 or 50mg/ kg) to rats 30 min before intraperitoneally injecting kainic acid (15mg/kg) increases seizure latency and decreases seizure score. In addition, hispidulin substantially attenuates kainic acid-induced hippocampal neuronal cell death, and this protective effect is accompanied by the suppression of microglial activation and the production of proinflammatory cytokines such as interleukin-1β, interleukin-6, and tumor necrosis factor-α in the hippocampus. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Epigenetics Compound Library | Immunology/Inflammation Compound Library | JAK/STAT Compound Library | Kinase Inhibitor Library | Natural Product Library | Anti-Cancer Compound Library | Lipid Compound Library | Phenols Library | Traditional Chinese Medicine Active Compound Library | Flavonoids Library | Anti-Pancreatic Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Obesity Compound Library | Food-Sourced Compound Library | Anti-Cancer Natural Product Library | Anti-inflammatory Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | Cancer Stem Cells Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compound Library Max | AZD1208 | CRT0066101 dihydrochloride | TP-3654 | PIM-447 dihydrochloride | Pim1/AKK1-IN-1 | SGI-1776 free base | CX-6258 | SMI-16a | SMI-4a | Quercetagetin | GDC-0339 | Uzansertib phosphate | TCS PIM-1 1 | CK2/ERK8-IN-1 | SEL24-B489 | CX-6258 hydrochloride | M-110 | PIM1-IN-1 | HTH-01-091 | HTH-01-091 TFA | HJ-PI01 | IBL-302 | PIM1-IN-2 | 10-DEBC | CDK6/PIM1-IN-1 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。