耗材描述
Quassin
产品活性:Quassin (Nigakilactone D) 是一种从 Quassia amara 的茎皮提取物中提取的生物活性三萜。Quassin 抑制 P. falciparum,IC50 为 0.15 μM。Quassin 具有可逆的避育能力,抗雌激素和抗疟原虫活性。
产品来源: https://www.medchemexpress.cn/quassin.html
研究领域:Anti-infection
作用靶点:Parasite
来源:植物 | 苦木科 | 苦木
结构分类:萜类 | 三萜
In Vitro: Quassin (Compound 1; 5-25 ng/mL) inhibits both the basal and luteinizing hormone-stimulated testosterone secretion of rat Leydig cells in a dose-dependent fashion.
In Vivo: Quassin (0.1-2.0 mg/kg; oral administration; daily; for 60 days; females albino rats) treatment shows a significant decrease in the weight of the ovary and uterus. And also shows a significant decrease in serum estrogen levels in quassin treated rats. The Quassin treated rats has a significantly decreased mean litter number and weight. Quassin does not adversely affect the weight of the kidney, heart, liver and the body of the rats.
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