Oroxin B 产品活性：Oroxin B (OB) 是一种从传统中草药 Oroxylum indicum (Linn.) Bentham ex Kurz 中分离出来的黄酮类化合物。 Oroxin B (OB) 通过上调 PTEN，下调 COX-2，VEGF，PI3K 和 p-AKT，对肝癌细胞具有明显的抑制作用，诱导细胞早期凋亡 (apoptosis)。Oroxin B (OB) 在恶性淋巴瘤细胞中诱导肿瘤抑制性 ER 应激。 产品来源： https://www.medchemexpress.cn/oroxin-b.html 研究领域：Apoptosis | PI3K/Akt/mTOR | Autophagy 作用靶点：Apoptosis | PI3K | PTEN | Autophagy 来源：植物 | 紫葳科 | 木蝴蝶 结构分类：黄酮类 | 黄酮 | 酚类 | 多酚类 | 结构分类 In Vitro: Oroxin B (0-2 μM, 48 h) inhibits the proliferation (48 h), and induces apoptosis (12 h) of the human hepatoma cell line (SMMC 7721). Oroxin B (0-2 μM, 48 h) increases PTEN and inhibits COX-2, VEGF, p-AKT, and PI3K in SMMC 7721. Oroxin B (0-30 μM, 48 h) selectively induces ER stressin (stress marker: glyburide labeled by rhodamine) in Raji cell. Oroxin B (160 μM, 24 h) inhibits IL-1β induced inflammation-related (iNOS, COX-2, TNF-α, IL-6, and IL-1β) markers in chondrocytes. In Vivo: Oroxin B (30 mg/kg, i.p., 28 days) induces malignant lymphoma cell ER stress, and inhibits tumor growth in human lymphoma cell (Raji cell) xenograft model. Oroxin B (160 μM of 10 μL, injected into the knee joints of mice) protects articular cartilage in destabilized medial meniscus (DMM) induced mice OA. Oroxin B (200 mg/kg/day, oral gavage) relieves hepatic inflammation and inhibits MAFLD progression in HFD-fed rats. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Apoptosis Compound Library | Immunology/Inflammation Compound Library | Kinase Inhibitor Library | PI3K/Akt/mTOR Compound Library | Stem Cell Signaling Compound Library | Natural Product Library | Anti-Cancer Compound Library | CNS-Penetrant Compound Library | Autophagy Compound Library | Anti-Aging Compound Library | Differentiation Inducing Compound Library | Glycoside Compound Library | Oxygen Sensing Compound Library | Endoplasmic Reticulum Stress Compound Library | Medicine Food Homology Compound Library | Phenols Library | Glycolysis Compound Library | Pyroptosis Compound Library | Cytoskeleton Compound Library | Orally Active Compound Library | Traditional Chinese Medicine Active Compound Library | Flavonoids Library | Anti-Breast Cancer Compound Library | Anti-Lung Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Obesity Compound Library | Angiogenesis-Related Compound Library | Glucose Metabolism Compound Library | Anti-Liver Cancer Compound Library | Anti-Colorectal Cancer Compound Library | Anti-Cancer Natural Product Library | Anti-inflammatory Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | Anti-Prostate Cancer Compound Library | Anti-Pulmonary Fibrosis Compound Library | Cancer Stem Cells Compound Library | Pain-Related Compound Library | Mitochondrial Protection Compound Library | Membrane Protein-targeted Compound Library | Highly Selective Inhibitors Library | Highly Selective Activators Library | Cell Death Library | Anti-Hematopathy Compound Library | Anti-Ovarian Cancer Compound Library | Multi-Target Compound Library | Bioactive Compound Library Max | Anti-Fibrosis Compound Library | MG-132 | 3-Methyladenine | Doxorubicin hydrochloride | Bafilomycin A1 | Tamoxifen | Y-27632 | LY294002 | Paclitaxel | Z-VAD-FMK | Acetylcysteine | Angiotensin II human | 2-Deoxy-D-glucose | Staurosporine | Actinomycin D | SB-431542 | 5-Fluorouracil | Bortezomib | Deferoxamine mesylate | Oxaliplatin | Trametinib | Sorafenib | Temozolomide | Gemcitabine | Decitabine | Mdivi-1 | Rotenone | Etoposide | Elesclomol | Ruxolitinib | Monomethyl auristatin E 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。