Mutanocyclin 产品活性：Mutanocyclin 是一种有效的抗真菌剂。Mutanocyclin 抑制白色念珠菌 (C. albicans) 丝状形成。Mutanocyclin 降低 HWP1、ECE1、FLO8、TEC1 的 mRNA 表达。Mutanocyclin 在离体小鼠体内抑制酵母形式。 产品来源： https://www.medchemexpress.cn/mutanocyclin.html 研究领域：Anti-infection 作用靶点：Fungal 结构分类：酮、醛、酸 | 结构分类 In Vitro: Mutanocyclin (8, 16, 32 µg/mL, 24, 36 h) inhibits Candida albicans (C. albicans) filamentation in a dose-dependent manner. Mutanocyclin (32 µg/mL) decreases the mRNA expression of HWP1, ECE1, FLO8, TEC1 in C. albicans cells. Mutanocyclin functions by regulating the PKA catabolic subunit Tpk2 and its preferential binding target Sfl1. In Vivo: Mutanocyclin (32 µg/mL; 24 h infects tongues of mouse) inhibits yeast-form in ex vivo mouse tongue infection models of C. albicans. Mutanocyclin (6.4, 12.8, 25.6 µg/mL; 48 h) attenuates the virulence of C. albicans in the G. mellonella infection model. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Anti-Infection Compound Library | Natural Product Library | Antifungal Compound Library | Microbial Metabolite Library | Bioactive Compound Library Max | Rapamycin | Ferrostatin-1 | Cycloheximide | Staurosporine | Hygromycin B | Resveratrol | Tunicamycin | Oligomycin | Camptothecin | Filipin complex | Amphotericin B | Calcimycin | Monensin sodium | Nystatin | Ketoconazole | Itraconazole | Fluconazole | Valinomycin | Tofacitinib citrate | Caspofungin diacetate | Mycophenolic acid | Leptomycin B | Idarubicin hydrochloride | Toyocamycin | Terbinafine | Hyperoside | Saponins | Sinefungin | Carvacrol 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。