耗材描述
9-Hydroxyoctadecanoic acid
产品活性:9-Hydroxyoctadecanoic acid (9-HSA) 是一种 HDAC1 抑制剂,在 5 μM 下可抑制约 66.4% 的 HDAC1 酶活性。9-Hydroxyoctadecanoic acid 显示抗癌活性。
产品来源: https://www.medchemexpress.cn/9-hydroxyoctadecanoic-acid.html
研究领域:Cell Cycle/DNA Damage | Epigenetics
作用靶点:HDAC
来源:植物 | 夹竹桃科 | 西非羊角拗
结构分类:酮、醛、酸 | 结构分类
In Vitro: 9-Hydroxyoctadecanoic acid (9-HSA) can bind to the active site of the three-dimensional model of the human HDAC1 protein.
9-Hydroxyoctadecanoic acid (9-HSA) (100 μM; 24 h) inhibits HT29 cell proliferation, induces arrest in G0/G1, and increases p21WAF1 expression both at the transcriptional and the translational levels.
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