Ginsenoside C-K 产品活性：Ginsenoside C-K 是一种 Ginsenoside Rb1 的细菌代谢物。Ginsenoside C-K 通过抑制诱生型一氧化氮合酶 (iNOS) 和 COX-2 来发挥抗炎作用。在人肝微粒体中，Ginsenoside C-K 抑制 CYP2C9 和 CYP2A6 活性，IC50 分别为 32.0±3.6 μM和 63.6±4.2 μM。 产品来源： https://www.medchemexpress.cn/Ginsenoside-C-K.html 研究领域：Immunology/Inflammation | Metabolic Enzyme/Protease 作用靶点：COX | NO Synthase | Cytochrome P450 来源：植物 | 五加科 | 人参 结构分类：萜类 | 三萜 In Vitro: Ginsenoside C-K, a bacterial metabolite of G-Rb1, exhibits anti-inflammatory effects mainly by reducing inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, and proinflammatory cytokines. Ginsenoside C-K suppresses the expression of proinflammatory cytokines by downregulating the activities of IRAK-1, MAPKs, IKK-α, and NF-κB in LPS-treated murine peritoneal macrophages. Ginsenoside C-K also suppresses the expression of iNOS and COX-2 by inhibiting NF-κB signaling in LPS-stimulated RAW264.7 cells. In zymosan-treated bone-marrow-derived macrophages (BMDMs) and RAW264.7 cells, Ginsenoside C-K inhibits inflammatory responses by negatively regulating the secretion of proinflammatory cytokines, the activation of MAPKs, and the generation of ROS. In addition, anti-inflammatory activity of Ginsenoside C-K has been observed in LPS-stimulated microglial cells. Ginsenoside C-K hinders inflammatory responses by controlling both the generation of ROS and the activities of MAPKs, NF-κB, and AP-1. Ginsenoside C-K, a major metabolite of ginsenosides in the gastrointestinal tract, inhibits NF-κB signaling in a PXR-dependent manner. Ginsenoside C-K is shown to promote recovery of dextran sulfate sodium (DSS) -induced colitis by suppressing NF-κB activation. Ginsenoside C-K significantly reduces TNF-α-induced upregulation of IL-1β and iNOS mRNA levels, and restores the mRNA levels of PXR and CYP3A4 in LS174T cells. Ginsenoside C-K, one of the intestinal metabolites of 20(S)-protopanaxadiol derivatives, exhibits an inhibition against the activity of CYP2C9 in human liver microsomes with an IC50 value of 32.0±3.6 μM, a weak inhibition against the activity of CYP2A6 in human liver microsomes with an IC50 value of 63.6±4.2 μM, and an even weaker inhibition against the activity of CYP2D6 in human liver microsomes with an IC50 value of more than 100 μM. In Vivo: The weight of the collagen-induced arthritis (CIA) mice increases slowly and is significantly less than that of the normal DBA/1 mice beginning on d 3 after injection of the emulsion. Ginsenoside C-K (28, 56, and 112 mg/kg) mice recover their weight by d 32 after the emulsion injection. Ginsenoside C-K (56 and 112 mg/kg) and Methotrexate (MTX)-treated (2 mg/kg) mice show significantly increased body weight on d 50 as compared with CIA mice. Hind paw-swelling began on d 24 post-immunization. CIA mice are treated from d 28 to d 50. Arthritis scores are measured every 4 d beginning on d 24. Ginsenoside C-K (56 and 112 mg/kg) significantly reduces the arthritis scores of the mice on d 51. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Metabolism/Protease Compound Library | Natural Product Library | Anti-Aging Compound Library | Antioxidant Compound Library | Glycoside Compound Library | Lipid Compound Library | Oxygen Sensing Compound Library | Antibacterial Compound Library | Medicine Food Homology Compound Library | Terpenoids Library | Pyroptosis Compound Library | Traditional Chinese Medicine Active Compound Library | Neuroprotective Compound Library | Anti-Pancreatic Cancer Compound Library | Angiogenesis-Related Compound Library | Mitochondria-Targeted Compound Library | Anti-Colorectal Cancer Compound Library | Antidepressant Compound Library | Anti-inflammatory Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | Human Metabolite Library | Anti-Prostate Cancer Compound Library | Anti-Pulmonary Fibrosis Compound Library | Mitochondrial Protection Compound Library | Metabolic Enzyme Compound Library | Membrane Protein-targeted Compound Library | Highly Selective Inhibitors Library | Multi-Target Compound Library | Radioprotector Library | Bioactive Compound Library Max | Acetaminophen | Indomethacin | L-NAME hydrochloride | Mifepristone | EIPA | Celecoxib | Verapamil | Aspirin | Apigenin | Fenofibrate | Midostaurin | Oxidopamine hydrobromide | L-Arginine | Chlorpromazine hydrochloride | Deferiprone | Ketoconazole | Abiraterone | Diclofenac | Letrozole | 1-Aminobenzotriazole | Itraconazole | Gallic acid | Ibuprofen | Cepharanthine | Quinidine (15% dihydroquinidine) | Clarithromycin 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。