IKarisoside A 产品活性：IKarisoside A (Icarisoside-A) 是一种天然黄酮醇糖苷，具有抗炎特性。 产品来源： https://www.medchemexpress.cn/IKarisoside-A.html 研究领域：Immunology/Inflammation 作用靶点：NO Synthase 来源：植物 | 小檗科 | 淫羊藿 结构分类：黄酮类 | 黄酮醇 | 结构分类 In Vitro: Ikarisoside A inhibited the expression of LPS-stimulated inducible nitric oxide synthase (iNOS) and the production of nitric oxide (NO) in LPS-stimulated RAW 264.7 cells and mouse bone marrow-derived macrophages (BMMs) in a concentration-dependent manner. In addition, Ikarisoside A reduced the release of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta). Furthermore, Ikarisoside A inhibited the activity of p38 kinase and nuclear factor-kappaB (NF-kappaB). Ikarisoside A is a potent inhibitor of osteoclastogenesis in RANKL-stimulated RAW 264.7 cells as well as in bone marrow-derived macrophages.The inhibitory effect of Ikarisoside A resulted in decrease of osteoclast-specific genes like matrix metalloproteinase 9 (MMP9), tartrate-resistant acid phosphatase (TRAP), receptor activator of NF-kappaB (RANK), and cathepsin K. Moreover, Ikarisoside A blocked the resorbing capacity of RAW 264.7 cells on calcium phosphate-coated plates. Ikarisoside A also has inhibitory effects on the RANKL-mediated activation of NF-kappaB, JNK, and Akt. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Natural Product Library | Anti-Aging Compound Library | Glycoside Compound Library | Lipid Compound Library | Traditional Chinese Medicine Active Compound Library | Flavonoids Library | Neuroprotective Compound Library | Angiogenesis-Related Compound Library | Anti-inflammatory Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | Heterocyclic Compound Library | Mitochondrial Protection Compound Library | Metabolic Enzyme Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compound Library Max | L-NAME hydrochloride | Mifepristone | Midostaurin | L-Arginine | DMPO | S-Nitroso-N-acetyl-DL-penicillamine | 1400W Dihydrochloride | DETA NONOate | Human serum albumin | Isoquercetin | Ethacrynic acid | Methylene Blue | Fucoxanthin | L-NMMA acetate | Chondroitin sulfate | Tetrahydrobiopterin | PRE-084 hydrochloride | 2,4-Diamino-6-hydroxypyrimidine | L-NIL | Aminoguanidine hydrochloride | Lipoamide | Asymmetric dimethylarginine | Carboxy-PTIO potassium | Avanafil | Prim-O-glucosylcimifugin | Agmatine sulfate | Ginsenoside C-K | 6-Biopterin | Tryptanthrin 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。